The internal solitary wave and mesoscale eddy are common mesoscale dynamic processes in the northern South China Sea. In this paper, we use the Terra/Aqua-MODIS, ENVISAT ASAR and multi-source satellite altimeter data from 2010 to 2015 to realize remote sensing of isolated waves and mesoscale eddy in the South China Sea, and analyze the influence of mesoscale eddy on the propagation direction of internal solitary wave. The results show that the mesoscale eddy and the internal solitary wave coexist mainly in the northeastern part of the South China Sea. When the two coexisted, the cyclone (cold eddy) caused the internal solitary wave to deviate from the original propagation direction and propagation and spread to the west-south direction. The anticyclonic (warm eddy) causes the internal solitary wave to spread westward to the north, and the cyclone and the anticyclone change the direction of the internal solitary wave propagation is just opposite. The coexistence time of internal solitary wave and mesoscale eddy is mainly concentrated from March to September, and the propagation direction of internal solitary wave is almost unchanged in March due to the interaction of cyclone and anticyclone. In April and May, the internal solitary wave deviated from its original propagation direction and propagated southward mainly due to cyclone. From June to September, the internal solitary wave deviated from its original direction and propagated northward, mainly under the influence of anticyclone. In April and May, the internal solitary wave deviated from its original propagation direction and propagated southward mainly due to cyclone. From June to September, the internal solitary wave deviated from its original direction and propagated northward, mainly under the influence of anticyclone. The effect of mesoscale eddy on the propagation direction of internal solitary wave is investigated by remote sensing, and the results are in agreement with the field observation.