The key regions for formation of the Antarctic Bottom Water occupied in the Indian sector of the Southern Ocean. The salinity change of the region has a profound influence on the global climate change. EN4 reanalysis-gridded data, measured seal data, WOD18 data combined with atmospheric reanalysis and sea ice concentration data were all used to explore the sea surface salinity changes in the Indian sector of the Southern Ocean and the response to large-scale circulation anomaly. The observation and reanalysis data both illustrated a significant positive surface salinity anomaly occurred in the Antarctic coast since 2008, especially in the Indian sector. The surface positive salinity anomaly was mainly centered in the Darnley Polynya and the north of Shackleton Ice Shelf. The high salinity shelf water expanded northward from the Antarctic coast and deepened. Meanwhile, the upwelling of Circumpolar Deep Water became increasingly distinct. Our study showed that this positive salinity anomaly was connected with the Antarctic Oscillation (AAO) and the Indian Ocean Dipole (IOD). During the positive AAO and IOD phases, the westerly wind enhanced significantly in the Indian sector and promoted the formation of sea ice, which increased surface salt flux. The significant negative wind curl and low pressure anomaly resulted in the upwelling of salty Circumpolar Deep Water and maintained the positive salinity anomaly. Additionally, increased locally zonal wind shear and enhanced evaporation were important factors as well.