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Advances in applications of deep learning for predicting sequence-based protein interactions
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Jingyong ZHU1, 2, 3, Junxiang LI3, 4, Xuhui LI3, 5, Jin ZHANG2, Wenjing WU2
Synthetic Biology Journal | 2024, 5(1) : 88 - 106
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Synthetic Biology Journal | 2024, 5(1): 88-106
Invited Review
Advances in applications of deep learning for predicting sequence-based protein interactions
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Jingyong ZHU1, 2, 3, Junxiang LI3, 4, Xuhui LI3, 5, Jin ZHANG2, Wenjing WU2
Affiliations
  • 1 College of Life Sciences and Medicine,Zhejiang Sci-tech University,Hangzhou 310018,Zhejiang,China
  • 2 College of Biological Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314000,Zhejiang,China
  • 3 Agecode R&D Center,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 341001,Zhejiang,China
  • 4 Harvest Biotech. Co. ,Ltd. ,Jiaxing 341001,Zhejiang,China
  • 5 Zhejiang Provincial Key Laboratory of Applied Enzymology,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314006,Zhejiang,China
Published: 2024-02-29 doi: 10.12211/2096-8280.2023-074
Outline
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Protein-protein interactions play a crucial role in biological processes such as cell signal transduction, gene expression and metabolic regulation, and thus their identification is essential for understanding these complex biological processes. Predicting protein-protein interactions is a hot topic of great significance, which can provide assistances in areas such as drug discovery and protein function research and design as well. In recent years, with the development of artificial intelligence, machine learning technologies have been applied gradually to the prediction of protein-protein interactions, which has shown good potentials. However, when processing a large amount of protein information, traditional machine learning methods are difficult to mine the intrinsic patterns and potential features, and deep learning techniques are needed. Compared with the three-dimensional structure of proteins, sequence information is easier to obtain, and the development of high-throughput sequencing technology provides abundant protein sequence information, which greatly facilitates the development of sequence-based deep learning technologies. Sequence-based deep learning models predict protein-protein interactions by learning intrinsic patterns and features from protein sequence information, which greatly improves prediction efficiency and accuracy. In this review, we focus on progress of deep learning in predicting sequence-based protein interactions, categorize, which is summarized according to the algorithmic framework and timeline, briefly describing the construction methods of datasets and the evaluation metrics of the models, discussing in detail the sequence encoding methods and common algorithmic architectures, and demonstrating the computational models based on various types of algorithms and their features and advantages. Finally, we analyze current challenges in predicting protein-protein interactions using deep learning methods, and discuss possible solutions. With the development of deep learning technology, the efficiency of predicting protein-protein interactions has increased dramatically. As a result, there is a need to develop models with stronger generalization and more robust prediction capabilities to aid the prediction of protein-protein interactions in the future.

protein interactions  /  deep learning  /  artificial intelligence  /  sequence encoding  /  neural network
Jingyong ZHU, Junxiang LI, Xuhui LI, Jin ZHANG, Wenjing WU. Advances in applications of deep learning for predicting sequence-based protein interactions[J]. Synthetic Biology Journal, 2024 , 5 (1) : 88 -106 . DOI: 10.12211/2096-8280.2023-074
Year 2024 volume 5 Issue 1
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Article Info
doi: 10.12211/2096-8280.2023-074
  • Receive Date:2023-10-24
  • Online Date:2025-07-07
  • Published:2024-02-29
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  • Received:2023-10-24
  • Revised:2023-11-28
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Affiliations
    1 College of Life Sciences and Medicine,Zhejiang Sci-tech University,Hangzhou 310018,Zhejiang,China
    2 College of Biological Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314000,Zhejiang,China
    3 Agecode R&D Center,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 341001,Zhejiang,China
    4 Harvest Biotech. Co. ,Ltd. ,Jiaxing 341001,Zhejiang,China
    5 Zhejiang Provincial Key Laboratory of Applied Enzymology,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314006,Zhejiang,China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
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占总种数比例
Percentage of
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Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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