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Price to Cost-of-raw-materials Ratio (PC) of biomanufacturing: definition and application
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Yi-Heng P. Job ZHANG1, 2, 3, Xuemei CHEN2, 3, Ting SHI1, 2, 3
Synthetic Biology Journal | 2025, 6(1) : 8 - 17
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Synthetic Biology Journal | 2025, 6(1): 8-17
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Price to Cost-of-raw-materials Ratio (PC) of biomanufacturing: definition and application
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Yi-Heng P. Job ZHANG1, 2, 3, Xuemei CHEN2, 3, Ting SHI1, 2, 3
Affiliations
  • 1 Key Laboratory of Engineering Biology for Low-Carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China
  • 2 In vitro Synthetic Biology Center,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China
  • 3 National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,China
Published: 2025-01-31 doi: 10.12211/2096-8280.2024-072
Outline
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Biomanufacturing is one of the strategic emerging industries in China during the “14th Five-Year Plan” period. The author once proposed “Tao-Fa-Shu-Qi” for the industrial biomanufacturing and provided its philosophical guideline. Focusing on the “Fa” of biological manufacturing and further analyzing the concept of “Fa as rules” in biomanufacturing, the author first proposed the concept of “Price to Cost-of-raw-materials Ratio” (PC value), which is the ratio of product market price to cost with raw materials. Biomanufactured products can be categorized by PC value into high-value products, value-added products, biocommodity, and products for public good. The PC value is a key indicator for evaluating the technological capability and economic viability of biomanufactured products. It is simple, transparent, and publicly accessible, offering a new approach for categorizing biomanufactured products. This indicator aids in guiding new technologies towards pathways of efficiency enhancement and cost reduction, forecasting future manufacturing costs and market prices for bioproducts, and assessing the industrialization potential of emerging biotechnologies. This article focuses on the biomanufacturing of fructose syrup, fructose solution, crystalline fructose, allulose, myo-inositol, and tagatose as examples, analyzing pathways for developing new technologies and predicting their economic feasibility. The calculation and analysis of the PC value could provide a new methodological tool for the top-level strategic design of the future development of emerging biomanufacturing industries, and could effectively facilitate the high-quality development of the bioeconomy.

biomanufacturing  /  bioeconomy  /  Price to Cost-of-raw-materials Ratio  /  Tao-Fa-Shu-Qi  /  first principles  /  biocommodity
Yi-Heng P. Job ZHANG, Xuemei CHEN, Ting SHI. Price to Cost-of-raw-materials Ratio (PC) of biomanufacturing: definition and application[J]. Synthetic Biology Journal, 2025 , 6 (1) : 8 -17 . DOI: 10.12211/2096-8280.2024-072
Year 2025 volume 6 Issue 1
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Article Info
doi: 10.12211/2096-8280.2024-072
  • Receive Date:2024-09-18
  • Online Date:2025-07-06
  • Published:2025-01-31
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History
  • Received:2024-09-18
  • Revised:2024-11-26
Funding
Affiliations
    1 Key Laboratory of Engineering Biology for Low-Carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China
    2 In vitro Synthetic Biology Center,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China
    3 National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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