To improve the comprehensive development efficiency of land along rail transit lines, guide the orderly development of urban rail transit stations, and ensure the supporting role of urban sustainable development, we conducted innovative research on the overall strategy of comprehensive transitoriented development (TOD) in Foshan based on a toplevel design. First, we outline the practical problems encountered by Foshan City, an important mega city in the Guangdong Hong Kong Macao Greater Bay Area, in the current stage of comprehensive development of rail transit, such as the lack of interest sharing mechanisms, failure to collect and store land along the line in advance, insufficient planning and coordination of station site selection, and mismatched timing between rail construction and comprehensive development. Subsequently, a comprehensive coordination framework for reasonable development is described. Development strategies are proposed, such as improving toplevel design, strengthening strategic coordination, advancing land preparation and storage, and exploring diversified land supply. Finally, using the land use planning practice along the second phase of construction planning for an urban rail transit line in Foshan City (Line 4 Phase I, Line 2 Phase II, and Line 11) as an example, toplevel policy challenges, toplevel planning challenges (coordination of national spatial planning and comprehensive transportation planning), land challenges (land preparation and storage, diversified land supply mode issues), and TOD construction mode challenges are discussed. We explore and establish a toplevel design practice path for comprehensive development that corresponds with the characteristics of Foshan City and propose an overall strategy for TOD comprehensive development that is suitable for the actual scenario in Foshan City. This can effectively guide the implementation of comprehensive development of land around stations along the line and provide valuable toplevel design practice experience and reference basis for similar metropolitan areas.