Subway carriages are ventilated from the outside world through fans, which regulate the temperature, humidity, and wind speed of the internal environment of the carriages, improve air quality, and enhance the thermal comfort of passengers. Due to the limited number of applicable thermal comfort evaluation indices, accurately determining the thermal comfort of subway car occupants in transient environments is challenging. This paper first focuses on occupants of a Btype subway compartment as the research subject and proposes the joint application of DRBerkeley thermal comfort evaluation indexes by considering both airflow comfort and heat sensation. The study then employs the Stolwijk physiological model of human thermal regulation to construct a threedimensional model of the amplitudeflow fan and an overall simulation model of the subway compartment. Finally, using CFD software, STARCCM+, the study analyzes the effects of different fan speeds, fan hood disturbance speeds, and fan air supply temperatures on the microenvironment and thermal comfort of the occupants under seven different conditions during the summer. The results show that the DRBerkeley thermal comfort evaluation indexes can reasonably evaluate the thermal comfort of subway compartments under the premise of meeting the airflow comfort in summer; increasing the fan speed, reducing the hood disturbance speed, and reducing the fan air supply temperature can improve the thermal comfort of the occupants; in the seven working conditions, the fan speed of 1,400 rpm, the hood disturbance speed of 3.25 rpm, and the air supply temperature of 20°C have a uniform temperature and speed distribution in the compartments. The temperature and velocity distributions in the cabin were uniform, the occupant microenvironmental heat flow field was optimal, and thermal comfort was 0.766. This method can solve the occupant thermal comfort problem more comprehensively, which is of some reference significance for optimizing the thermal flow field environment in subway compartments and upgrading occupant thermal comfort.