Monorail transportation systems currently face challenges such as relatively independent specialties, numerous workstation terminals, high usage, and elevated management and maintenance costs. Additionally, data interconnectivity between subsystems is lacking, making coordination and command difficult in the event of faults or accidents. This paper presents a comprehensive analysis and research on these issues, focusing on data control, subsystem business implementation, and operation and maintenance requirements. The paper elaborates on an architecture scheme for a deeply integrated monorail comprehensive operation and dispatch system based on a unified software/hardware platform and humanmachine interface across various professional subsystems. It explores the application of this scheme in different scenarios, including upgrading existing lines, constructing new lines, and achieving networklevel integration. The proposed system addresses the needs of data control and comprehensive intelligent operation and maintenance by integrating the architecture of center, station, and depot/parking lot system equipment, as well as integrating or interfacing various subsystems. This allows for monitoring and control of various professional system equipment on a unified platform. The analysis demonstrates that adopting a single track system with comprehensive operation scheduling significantly enhances system integration, simplifies job positions, and effectively reduces construction and operation costs. The comprehensive operation and dispatch system enables the interconnection and sharing of various professional resources, providing users with complete and rich information support within a unified platform during emergencies or equipment failures. Through intelligent linkage and other automatic control technologies, operational efficiency can be considerably improved. The integrated operation and dispatch system solution aligns with the development direction of integrated, simplified, and streamlined monorail transportation systems. It is expected to be the future trend for China’s monorail transportation operation and control systems.