Full
Outline
Recombinant collagen hydrogels are ideal materials for promoting wound healing but currently suffer from weak mechanical strength and single functionality，which limit their practical applications. A multifunctional hydrogel with a multi-network structure polymethylacrylamide-acrylic acid/tannic acid/recombinant collagen （MA-AAC/TA/COL） is preparedusing in-situ polymerization. The main raw materials include recombinant collagen，tannic acid，methylacrylamide，and acrylic acid. The microstructure，mechanical properties，swelling performance，adhesive property，self-healing ability，antioxidant activity，antibacterial performance，and biocompatibility of hydrogels with different components are explored. The results show that the multi-network structure design effectively enhances the mechanical properties of the hydrogel. Its maximum tensile strain reaches （250.2±2.7）% and maximum tensile stress is （130±3） kPa. It can withstand 80% compressive deformation without breaking and the maximum compressive strength is （4.23±0.18） MPa. The hydrogel exhibits certain pH sensitivity with different swelling rates under various pH conditions. It has a maximum adhesive strength of （36.27±5.03） kPa on pig skin，a self-healing rate of 67.7% and an in-vitro antioxidant rate of （80.2±0.9）%. It shows good antibacterial effects against E.coli and S.aureus with an antibacterial rate close to 99.99%. Additionally，the hydrogel has low cytotoxicity with a cell survival rate greater than 80%. The MA-AAC/TA/COL hydrogel is expected to serve as a multifunctional wound dressing and find application in the field of wound treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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