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Outline
In addressing the inadequate water solubility and bioavailability of baicalin， this study develops a drug carrier that exhibits both antimicrobial and self-healing hydrogel by integrating konjac glucomannan （KGM）-based hydrogel with cyclodextrin encapsulation technology. The successful preparation of baicalin/hydroxypropyl-β-cyclodextrin inclusion complexes is achieved through the utilisation of a saturated solution stirring-freeze-drying method. Subsequent FTIR and XRD analysis demonstrates the effective inclusion of baicalin within the cyclodextrin cavity. The inclusion complexes are loaded into KGM/sodium tetraborate dynamically crosslinked hydrogels， and the resulting hydrogels exhibit excellent swelling properties with a swelling rate of 630.23%. Mechanical tests demonstrate that the hydrogel has significant self-healing capability， with a tensile strength retention rate of 97.80% after healing. In vitro release experiments demonstrate that the system conforms to First-order release model， the cumulative release rate of baicalin reaches 84.33% at 48 h. Antimicrobial experiments confirm that its inhibition rate against Staphylococcus aureus， Escherichia coli and Candida albicans reaches 99.12%， 98.07% and 98.82%， respectively， and the DPPH radical scavenging rate is as high as 93.54%. This study proposes a viable methodology for the development of innovative antimicrobial materials and drug carriers， addressing the challenges of low solubility and poor stability associated with baicalin.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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