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Synthesis of multifunctional cuttlefish-ink@CuO composite nanomaterials for photothermal-chemodynamic therapy of cancer cells
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Yan LI1, Wen ZHANG2, Wei WANG1, Peng GENG1, 3, Haichuang LAN1, Shuzhang XIAO1, 3
Journal of Materials Engineering | 2026, 54(9) : 244 - 252
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Journal of Materials Engineering | 2026, 54(9): 244-252
• RESEARCH ARTICLE •
Synthesis of multifunctional cuttlefish-ink@CuO composite nanomaterials for photothermal-chemodynamic therapy of cancer cells
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Yan LI1, Wen ZHANG2, Wei WANG1, Peng GENG1, 3, Haichuang LAN1, Shuzhang XIAO1, 3
Affiliations
  • 1.Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials，College of Materials and Chemical Engineering，China Three Gorges University，Yichang 443002，Hubei，China
  • 2.College of Biological and Pharmaceutical Sciences，China Three Gorges University，Yichang 443002，Hubei，China
  • 3.Hubei Three Gorges Laboratory，Yichang 443007，Hubei，China
Published: 2026-09-20 doi: 10.11868/j.issn.1001-4381.2024.000562
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Nanomaterials with combined photothermal-chemodynamic therapy （PTT-CDT） offer significant advantages in cancer treatment， yet designing and fabricating such multifunctional nanomaterials remains challenging. In this study， cuttlefish ink （M） is used as a core， onto which a layer of CuO is grown， successfully constructing the M@CuO composite multifunctional nanomaterial. The results show that the M@CuO exhibits a spherical shape with a nanoparticle size of 128.2 nm and demonstrates excellent photothermal conversion efficiency （ηT=47.6%） under near-infrared light irradiation. Additionally， the M@CuO shows a strong Fenton effect at room temperature （25 ℃）， and the Fenton reaction rate can be further enhanced by the photothermal effect， with the reaction rate at 45 ℃ being 2.3 times that at 25 ℃ under the same conditions. In vitro cell experiments reveal that M@CuO has good biocompatibility and can effectively kill tumor cells through combined PTT-CDT. Therefore， M@CuO provides an effective strategy for developing multifunctional nanomaterials with PTT-CDT synergistic therapy.

cuttlefish ink  /  copper oxide  /  photothermal therapy  /  chemodynamic therapy  /  combined therapy
李燕, 张文, 王玮, 耿鹏, 兰海闯, 肖述章. 多功能墨鱼汁@氧化铜复合纳米材料的合成及应用于癌细胞的光热-化学动力学联合治疗. 材料工程, 2026 , 54 (9) : 244 -252 . DOI: 10.11868/j.issn.1001-4381.2024.000562
Yan LI, Wen ZHANG, Wei WANG, Peng GENG, Haichuang LAN, Shuzhang XIAO. Synthesis of multifunctional cuttlefish-ink@CuO composite nanomaterials for photothermal-chemodynamic therapy of cancer cells[J]. Journal of Materials Engineering, 2026 , 54 (9) : 244 -252 . DOI: 10.11868/j.issn.1001-4381.2024.000562
Appendix
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Year 2026 volume 54 Issue 9
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Article Info
doi: 10.11868/j.issn.1001-4381.2024.000562
  • Receive Date：2024-08-12
  • Online Date：2026-10-28
  • Published：2026-09-20
Article Data
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History
  • Received：2024-08-12
  • Accepted：2024-10-09
Funding
Affiliations
    1.Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials，College of Materials and Chemical Engineering，China Three Gorges University，Yichang 443002，Hubei，China
    2.College of Biological and Pharmaceutical Sciences，China Three Gorges University，Yichang 443002，Hubei，China
    3.Hubei Three Gorges Laboratory，Yichang 443007，Hubei，China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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