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Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products
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Xia Wei1, 2, Lishuang Guo4, Xuewei Duan1, Zekun Zhang1, Linkun An4, *, Juncheng Su3, *, Cuixian Zhang1, *
Chinese Journal of Natural Medicines | 2026, 24(8) : 1015 - 1024
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Chinese Journal of Natural Medicines | 2026, 24(8): 1015-1024
• Original Article •
Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products
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Xia Wei1, 2, Lishuang Guo4, Xuewei Duan1, Zekun Zhang1, Linkun An4, *, Juncheng Su3, *, Cuixian Zhang1, *
Affiliations
  • 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
  • 2Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China
  • 3State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
  • 4School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
About Author:

∆

These authors contributed equally to this work.

Published: 2026-08-20 doi: 10.1016/S1875-5364(26)61199-5
Outline
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Systematical screening of the metabolic profile of marine fungus Aspergillus sp. EGF 15-0-3 using OSMAC-GNPS molecular networking cascade followed by target isolation of the environmental-induced products resulted the identification of eight unprecedented indole diketopiperazine-based hybrids (1−8) featuring three distinct chemical backbones. The structures of the obtained compounds were established by combination of extensive spectroscopic analyses, X-ray crystallography, and ECD calculations. All these environmental-induced metabolites were demonstrated to be unusual tyrosyl-DNA phosphodiesterase 2 inhibitors. Compound 3, as the most outstanding example, showed selective synergistic antitumor effect when combined with the chemotherapeutic drugs.

Environmental-induced products  /  TDPs inhibitory activities  /  Combined anti-tumor activities  /  Marine fungus  /  Aspergillus sp. EGF 15-0-3
Xia Wei, Lishuang Guo, Xuewei Duan, Zekun Zhang, Linkun An, Juncheng Su, Cuixian Zhang. Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products[J]. Chinese Journal of Natural Medicines, 2026 , 24 (8) : 1015 -1024 . DOI: 10.1016/S1875-5364(26)61199-5
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Funding
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  • National Natural Science Foundation of China(82273845; 82304331; 82360695; and 82173655)
  • Guangxi Natural Science Foundation Project(2023GXNSFBA026236)
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Year 2026 volume 24 Issue 8
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72
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Article Info
doi: 10.1016/S1875-5364(26)61199-5
  • Receive Date：2025-09-11
  • Online Date：2026-08-20
  • Published：2026-08-20
Article Data
Affiliations
History
  • Received：2025-09-11
  • Revised：2025-12-01
  • Accepted：2026-02-22
Funding
National Natural Science Foundation of China(82273845; 82304331; 82360695; and 82173655)
Guangxi Natural Science Foundation Project(2023GXNSFBA026236)
Affiliations
    1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
    2Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China
    3State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
    4School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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