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Patchouli alcohol protects against ulcerative colitis by alleviating ER stress and dysbiosis-mediated intestinal epithelial injury
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Sha Feng, Wenhui Li, Xuqing Zhang, Qiyue Lin, Juyi Tian, Ruolin Wang, Lixia Yuan*, Piao Luo*, Qian Zhang*
Chinese Journal of Natural Medicines | 2026, 24(8) : 929 - 940
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Chinese Journal of Natural Medicines | 2026, 24(8): 929-940
• Original Article •
Patchouli alcohol protects against ulcerative colitis by alleviating ER stress and dysbiosis-mediated intestinal epithelial injury
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Sha Feng, Wenhui Li, Xuqing Zhang, Qiyue Lin, Juyi Tian, Ruolin Wang, Lixia Yuan*, Piao Luo*, Qian Zhang*
Affiliations
  • Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
About Author:

∆

These authors contributed equally to this work.

Published: 2026-08-20 doi: 10.1016/S1875-5364(26)61194-6
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Ulcerative colitis (UC) is defined as a chronic inflammatory disease with recurrent episodes, and current therapeutic strategies for this gastrointestinal disorder often fail to achieve satisfactory clinical outcomes. This clinical challenge underscores an urgent requirement to develop alternative treatment strategies. Patchouli alcohol (PA), a natural compound exhibiting anti-inflammatory and antioxidant properties, has shown potential; however, its precise mechanisms of action in UC remain to be fully elucidated. Our study shows that PA can effectively alleviate the symptoms of dextran sulfate sodium (DSS)-induced UC in mice. This therapeutic effect is achieved by reducing intestinal barrier impairment and inhibiting inflammatory reactions. In an LPS-induced inflammatory model using RAW264.7 cells, PA significantly downregulated the mRNA expression of il-1β and il-6. Mechanistically, protein disulfide isomerase (PDI) was identified as a direct target of PA. By inhibiting IRE1 activation via PDI, PA mitigates endoplasmic reticulum stress, thereby reducing intestinal epithelial injury and ultimately alleviating the severity of UC. In this research, it is determined that the ability of PA to protect the intestinal epithelial barrier is brought about by its specific targeting of PDI, which alleviates consequent endoplasmic reticulum stress and prevents cellular damage.

Ulcerative colitis  /  Patchouli alcohol  /  Protein disulfide-isomerase  /  Endoplasmic reticulum stress  /  Gut microbiota
Sha Feng, Wenhui Li, Xuqing Zhang, Qiyue Lin, Juyi Tian, Ruolin Wang, Lixia Yuan, Piao Luo, Qian Zhang. Patchouli alcohol protects against ulcerative colitis by alleviating ER stress and dysbiosis-mediated intestinal epithelial injury[J]. Chinese Journal of Natural Medicines, 2026 , 24 (8) : 929 -940 . DOI: 10.1016/S1875-5364(26)61194-6
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Funding
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  • GuangDong Basic and Applied Basic Research Foundation(2025A1515011816)
  • National Natural Science Foundation of China(82305014; 82304827; 82274387)
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Year 2026 volume 24 Issue 8
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Article Info
doi: 10.1016/S1875-5364(26)61194-6
  • Receive Date：2025-10-31
  • Online Date：2026-08-20
  • Published：2026-08-20
Article Data
Affiliations
History
  • Received：2025-10-31
  • Revised：2025-12-21
  • Accepted：2026-02-09
Funding
GuangDong Basic and Applied Basic Research Foundation(2025A1515011816)
National Natural Science Foundation of China(82305014; 82304827; 82274387)
Affiliations
    Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

Corresponding:

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E-mail address: (L. Yuan)
(P. Luo)
(Q. Zhang)
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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