Latest ArticlesIntegrating silica with organic nanoparticles can generate unique properties. Here pillar[5]arene/silica hybrid vesicles were constructed based on the amphiphilic and rigid properties of pillararenes, as well as the catalytic hydrolysis of tetraethoxysilane. Such vesicles exhibited the high strength of silica and unique molecular recognition of pillararenes, both of which could tune the pH-triggered release behavior. Furthermore, a rhodamine B derivative with hexyl group (RhB-C6) was synthesized, which can form a complex with the pillar[5]arene. Based on the host-guest interaction and high strength of silica, the hybrid vesicles could load more RhB-C6 and the rhodamine B was released more slowly compared with the organic vesicles.
Selection of aptamers with high affinity and good specificity requires multiple rounds of alternating steps of separation and PCR amplification. Herein, we proposed a novel high-efficiency aptamers picking strategy: One-round pressure controllable selection (OPCS). OPCS integrates four types of screening superiority, high-efficiency separation, one-round selection and PCR amplification, synchronous negative selection and targets competition. The controllable screening pressure can be achieved through two approaches, balanced competition by the regulation of protein concentration, and dominant competition by introducing a predatory protein with high concentration. In OPCS process, two proteins were co-incubated with one ssDNA library, and each protein bound its favorable sequences specifically and formed protein-ssDNA complex respectively. Meanwhile, one protein could supply/suffer the picking pressure of affinity and specificity to/from another, which eliminated weakly bound or unbound sequences for each other. Two complexes could be separated and collected conveniently, and aptamers for two proteins obtained synchronously with high affinity and good specificity. This strategy not only provides a more effective way for aptamers selection, but shows great potential in other ligands or drugs selection.
The metabolic disorder of glucose in human body will cause diseases such as diabetes and hyperglycemia. Hence the determination of glucose content is very important in clinic diagnosing. In recent years, researchers have proposed various non-invasive wearable sensors for rapid and real-time glucose monitoring from human body fluids. Unlike those reviews which discussed performances, detection environments or substrates of the wearable glucose sensor, this review focuses on the sensing nanomaterials since they are the key elements of most wearable glucose sensors. The sensing nanomaterials such as carbon, metals, and conductive polymers are summarized in detail. And also the structural characteristics of different sensing nanomaterials and the corresponding wearable glucose sensors are highlighted. Finally, we prospect the future development requirements of sensing nanomaterials for wearable glucose sensors. This review would give some insights to the further development of wearable glucose sensors and the modern medical treatment.
Recent advances in non-fullerene acceptors (NFAs), typically Y6, have driven power conversion efficiency (PCE) of single-junction organic solar cells (OSCs) over 16%. Meanwhile, it becomes essential to know how to adopt simple strategies to further improve device performance. In this work, a new A-DA'D-A acceptor derivative, Y19-N3 employing 3-ethylheptyl branched at the 3rd-position instead of 2-ethylhexyl on the pyrroles of Y19 is reported. The selection of an appropriate solvent in casting device is implemented to maximize the photovoltaic performance. PBDB-T: Y19-N3-based OSCs treated with a ternary solvent of CF/CB (1:3, v/v) and 0.8% DIO exhibit the optimal PCE of 13.77% here, with the significantly improved Voc (0.78 V) and FF (0.72) as well as the high Jsc (24.46 mA/cm2). Further characterizations indicate that this ternary solvent-treated PBDB-T/Y19-N3 film exhibits the more appropriate morphological features with the highly efficient charge generation and collection as well as the more balanced electron and hole mobilities. This work combines molecular design and device engineering to improve the photovoltaic properties, which is important to the development of OSCs.
In this study, a promising strategy has been developed to promote bone regeneration by combining antioxidant activities and osteoimmunomodulatory properties. Herein, an L-arginine/nanofish bone (Arg/NFB) nanocomplex has been prepared and evaluated in vitro and in vivo. The Arg/NFB nanocomplex possesses good antioxidant activities and could modulate the polarization of non-activated macrophage into different types and induce the secretion of pre-inflammatory, anti-inflammatory, osteogenic as well as angiogenic cytokines. Additionally, the regulated immune microenvironment can enhance the osteogenic differentiation of mouse embryo osteoblast precursor cells (MC3T3-E1) and angiogenic capacity of human umbilical vein endothelial cells (HUVECs), leading to the improved formation of mineralized nodules, alkaline phosphatase activity and angiogenic effects. In vivo results with cranial defect models reveal that the treatment of Arg/NFB nanocomplex exhibited significant improvement of new bone formation and angiogenesis. All the results demonstrate Arg/NFB nanocomplex with antioxidant activities and osteoimmunomodulatory properties could be a new idea for developing the next generation of bone regeneration biomaterials.
(S, S)-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C–H functionalization of N-ferrocenyl o-bromo-benzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee. The products can be transformed into planar chiral ferrocenyl monophosphines, which demonstrate their preliminary application.
Polymeric nanomedicine is a promising and rapidly evolving field. Among the different polymeric carriers, polymeric micelle (PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics, enhanced efficacy and lower toxicity. PM has garnered increasing interest in research and in the clinic. This review will highlight the clinical outcomes of several PM-based formulations, and further summarized their preparation methods, strengths and challenges.
A facile and metal-free visible-light-enabled three-component reaction of quinoxalin-2(1H)-ones, alkenes and CF3SO2Na has been developed under air at room temperature. This photocatalytic tandem reaction using 4CzIPN as the photocatalyst and air as the green oxidant, provides a mild and environmentally friendly approach to access a series of 3-trifluoroalkylated quinoxalin-2(1H)-ones.
Two fluoride sulfates, K2Mn3(SO4)3F2·4H2O (I) and Rb2Mn3(SO4)3F2·2H2O (Π) are obtained by water solution method. Single-crystal X-ray diffraction analysis indicated that they crystallize in space groups of Cmc21. Their structures feature a pseudo-KTP structure consisting of interconnecting [Mn3(SO4)3F2(H2O)2]∞ layers, which are further packing along the a axis with alkali metal cations balancing the charges. The structure relationships between the two compounds are discussed. Second-harmonic generation measurements manifest that I and Π have similar second-harmonic generation responses of about 0.2 and 0.25 times that of KH2PO4.
For bone regenerative engineering, it is a promising method to form skeletal tissues differentiating from human bone morrow mesenchyme stem cells (hBMSCs). However, it is still a critical challenge to efficiently control ostogenesis and clearly reveal the influence factor. To this end, the fluorescent gold nanodots (Au NDs) with highly negative charges as osteogenic induction reagent are successfully synthesized, which display better than commercial osteogenic induction medium through the investigations of ALP activity (2.5 folds) and cytoskeleton staining (1.5 folds). Two kinds of oligopeptides with different bio-structures (cysteine, Cys and glutathione, GSH) are selected for providing surficial charges on Au NDs. It is revealed that Au-Cys with more negative charges (-51 mV) play better role than Au-GSH (-19 mV) in osteogenic differentiation, when both of them have same size (~2 nm), sphere shape and show similar cell uptake amount. To explore deeply, osteogenesis related signaling pathways are monitored, revealing that the enhancement of osteogenic differentiation was through autophagy signaling pathway triggered by Au-Cys. And the promotion of highly negative charges in osteogenic differentiation was further proved via sliver nanodots (Ag NDs, Ag-Cys and Ag-GSH) and carbon nanodots (CDs, Cys-CDs and GSH-CDs). This work indicates part of insights during hBMSCs differentiation and provides a novel strategy in osteogenic differentiation process.
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