Latest ArticlesIn this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTT assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo Ⅱ inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy.
A range of bench-stable carbazole-containing hypervalent iodine(Ⅲ) reagents were synthesized by I-N bond formation in good yields. This kind of benziodoxolone reagents was used for a C-N coupling reaction to introduce a carbazole group to aromatic heterocycle compounds.
This article describes a fast and simple electrochemical assay for detecting cell concentration. After cell death, the membrane of cells will be broken, and DNA molecules contained in the cells will be released, but this does not happen in living cells. Sodium molybdate can react with the phosphate backbone of the released DNA molecules to form phosphomolybdate precipitation and produces a corresponding redox current. The higher the concentration of DNA, the stronger the intensity of the current generated. Sodium molybdate solution and centrifuged cell supernatant were added onto the glassy carbon electrode to determine the cell concentration by measuring the current intensity. The cell viability, which means the ratio of living cells to the total cells, can also be determined by this method. This assay has the advantages of high sensitivity, low detection limit, and wide detection range. In addition, this method was successfully applied to the detection of cell concentration in human serum, which has potential clinical applications.
Nitrogen doping is a promising way to modulate the electrical properties of graphene to realize graphene-based electronics and promise fascinating properties and applications. Herein, we report a method to noncovalently assembly titanium(Ⅳ) bis(ammoniumlactato) dihydroxide (Ti complex) on nitrogen-doped graphene to create a reliable hybrids which can be used as a reversible chemical induced switching. As the adsorption and desorption of Ti complex in sequential treatments, the conductance of the nitrogen-doped graphene transistors was finely modulated. Control experiments with pristine graphene clearly demonstrated the important effort of the nitrogen in this chemical sensor. Under optimized conditions, nitrogen-doped graphene transistors open up new ways to develop multifunctional devices with high sensitivity.
ZnO-CeO2/SBA-15 catalysts were prepared by two kinds of solid-state grinding method and used for the production of 1, 3-butadiene (1, 3-BD) from ethanol. A mixture of SBA-15 (with or without organic template) and metal precursors were ground in solid-state. The obtained catalysts were characterized by TG, N2 adsorption-desorption, TEM, XRD, Py-FTIR and NH3-TPD techniques. Superior dispersion of metal oxides and more exposed acid sites were achieved on the catalyst 10Zn1Ce5-AS with the presence of organic template in SBA-15 during the solid-state grinding process. The catalytic performance was evaluated in a fixed-bed reactor and a 1, 3-butadiene selectivity of as high as 45% is achieved. This is attributed to the coupling effect of Zn and Ce species in the mesopores of SBA-15, in which Zn promotes ethanol dehydrogenation and Ce enhances aldol-condensation, respectively. Additionally, solvent-free method inspires new catalyst synthesis strategy for the production of 1, 3-butadiene from ethanol.
Pore size and distribution in carbon-based materials are regarded to be a key factor to affect the electrochemical capacitive performances of the resultant electrodes. In this study, nitrogen and oxygen codoped porous carbons (NOPCs) are fabricated based on a simple Schiff-base reaction between m-phenylenediamine and terephthalaldehyde. The NOPCs have tunable morphologies, high surface areas, abundant heteroatom doping. More importantly, the carbons show a dominant micropores of 0.5-0.8 nm, comparable to the ionic sizes of LiTFSI (Li+ 0.069 nm; TFSI-0.79 nm) water-in-salt electrolyte with a high potential window of 2.2 V. Consequently, the fabricated symmetric supercapacitor gives a high energy output of 30.5 Wh/kg at 1 kW/kg, and high stability after successive 10, 000 cycles with ~96.8% retention. This study provides promising potential to develop high-energy supercapacitors.
X-ray imaging functionalization of biodegradable polyesters is a great demand and challenge in biomedical applications. In this work, a strategy of in-chain functionalization through the combination of ring opening copolymerization and oxime "Click" postfunctionalization was developed towards X-ray opaque polylactide copolymers. A functionalized cyclic carbonate was first synthesized and used as comonomer of polylactide copolymers, which were subjected to postfunctionalization of oxime "Click" reaction towards iodinated polylactide copolymers. The chemical structure and physical properties of the target products were traced and confirmed. In vitro cytotoxicity evaluation with 3T3-Swiss albino by Alamar blue demonstrated a low cytotoxicity. The X-ray radiopacity was analyzed by Micro-CT and quantified by Hounsfield Units value, which could be tailorable by the feedstock. It is a promising X-ray visible implantable biomaterial in biomedical applications.
In this paper, we introduced a novel method to prepare the few-layer nitrogen-doped graphene (FNG) from expandable graphite with melamine. The super-capacitive properties of FNG were thoroughly characterized by a three-electrode system, and the results showed the FNG electrode achieved a specific capacitance as high as 83.8 mF/cm2 together with excellent cycling stability. This method could be a novel approach to combine the pseudo-capacitors and electric double layer capacitors.
A series of Tm3+/Dy3+ co-doped Ba3LaNa(PO4)3F (BLNPF) phosphors were synthesized successfully via a high-temperature solid-reaction, and luminescence properties were investigated. Upon near violet excitation, BLNPF:Tm3+, Dy3+ phosphors exhibit Tm3+:1D2-3F4 and Dy3+:4F9/2-6HJ (J = 15/2, 13/2, 11/2) transitions with different luminescence intensity. The emitting color of the obtained products was found to shift from blue to white as a result of efficient energy transfer (ET) from Tm3+ to Dy3+ ions. According to photoluminescence emission intensity, the positive effect of activator on ETefficiency was calculated and the maximum ET efficiency was found around 72.6% with Dy3+ concentration was 0.04. By means of Dexter's theoretical model, furthermore, dipole-dipole interaction was confirmed as the mechanism of energy transfer from Tm3+ to Dy3+ ions. The results suggested that BLNPF:Tm3+, Dy3+ phosphor might be a promising single-phased white-light-emitting phosphor for UV white-light LED.
Volume expansion and polysulfide shuttle effect are the main barriers for the commercialization of lithium-sulfur (Li-S) battery. In this work, we in-situ polymerized a cross-linked binder in sulfur cathode to solve the aforementioned problems using a facile method under mild conditions. Polycarbonate diol (PCDL), triethanolamine (TEA) and hexamethylene diisocyanate (HDI) were chosen as precursors to prepare the cross-linked binder. The in-situ polymerized binder (PTH) builds a strong network in sulfur cathode, which could restrain the volume expansion of sulfur. Moreover, by adopting functional groups of oxygen atoms and nitrogen atoms, the binder could effectively facilitate transportation of Li-ion and adsorb polysulfide chemically. The Li-S battery with bare sulfur and carbon/sulfur composite cathodes and cross-linked PTH binder displays much better electrochemical performance than that of the battery with PVDF. The PTH-bare S cathode with a mass loading of 5.97 mg/cm2 could deliver a capacity of 733.3 mAh/g at 0.2 C, and remained 585.5 mAh/g after 100 cycles. This in-situ polymerized binder is proved to be quite effective on restraining the volume expansion and suppressing polysulfide shuttle effect, then improving the electrochemical performance of Li-S battery.
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