Latest ArticlesA facile and efficient strategy has been developed to fabricate a multifunctional, theranostic anticancer drug delivery platform featuring active targeting, controlled drug release and fluorescence imaging for real-time control of delivery. To this end, thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform. A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin (DOX), target cells and reduce Au3+ ions to form luminescent Au clusters. Importantly, the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions, significantly improving their stability in biological medium and drug release efficiency. The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions.
Botrytis cinerea is a necrotrophic fungus that affects various plant species. Chemical control is a necessity and as much as possible, eco-friendly conditions and bioresources to obtain these chemicals should be used. In this context, a series of products was obtained from salicylaldehyde using zinc as a powerful reagent and tested for antifungal activity against Botrytis cinerea.
Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity, which are suitable for growth and development of different types of cells. Due to the huge advantages of both resorbable polymers and electrospun nanofibers, resorbable polymer electrospun nanofibers (RPENs) have been widely applied in the field of tissue engineering. In this paper, we will mainly introduce RPENs for tissue engineering. Firstly, the electrospinning technique and electrospun nanofiber architectures are briefly introduced. Secondly, the application of RPENs in the field of tissue engineering is mainly reviewed. Finally, the advantages and disadvantages of RPENs for tissue engineering are discussed. This review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.
Based on block copolymer assisted topochemical polymerization, a new strategy for facilely producing robust nanoporous membranes with controlled incorporation of functional groups onto nanopores is developed. As exemplified by preparing nanoporous polypyrrole decorated with amino acids, this strategy exhibits a high degree of freedom for tailoring the surface functionality in the created pores.
Electronic polarization has an important impact on the site energies of charge carriers that play a key role in determining the charge transport in organic semiconductors. Dipolar molecules have strong intermolecular interactions and widespread applications in organic optoelectronics. However, compared with nonpolar organic semiconductors, electronic polarization for dipolar systems has been rarely studied. Here, taking 1, 2, 3, 4-tetrafluoro-6, 7-dimethylnaphthalene as representative, we have calculated the electronic polarization energies of dipolar organic molecular crystals by means of a polarizable forcefield method. Surprisingly, our results point to that the polarization energies for this dipolar system are similar to those of nonpolar systems. In addition, the π-π stack contributes only about 30%~40% to the total polarization energy, thus the polarization effects along the three dimensions should be treated equally even for the one-dimensional stacking crystals.
Enantiomerically pure 2-substituted indolines are an important class of nitrogen heterocycles that occur frequently in many alkaloid natural products and biologically active compounds. Consequently, the synthesis of such skeletons is of great significance. The past years have witnessed a number of remarkable advances in the development of efficient strategies to construct this class of chiral compounds. This review summarizes the recent advances in asymmetric synthesis of 2-substituted indoline derivatives. Due to the limitation of the length, this review only summarizes those works published from January of 2012 to January of 2019. Meanwhile, methods towards synthesis of fused and spirocyclic indolines will not be discussed in this review.
ZnO-CeO2/SBA-15 catalysts were prepared by two kinds of solid-state grinding method and used for the production of 1, 3-butadiene (1, 3-BD) from ethanol. A mixture of SBA-15 (with or without organic template) and metal precursors were ground in solid-state. The obtained catalysts were characterized by TG, N2 adsorption-desorption, TEM, XRD, Py-FTIR and NH3-TPD techniques. Superior dispersion of metal oxides and more exposed acid sites were achieved on the catalyst 10Zn1Ce5-AS with the presence of organic template in SBA-15 during the solid-state grinding process. The catalytic performance was evaluated in a fixed-bed reactor and a 1, 3-butadiene selectivity of as high as 45% is achieved. This is attributed to the coupling effect of Zn and Ce species in the mesopores of SBA-15, in which Zn promotes ethanol dehydrogenation and Ce enhances aldol-condensation, respectively. Additionally, solvent-free method inspires new catalyst synthesis strategy for the production of 1, 3-butadiene from ethanol.
Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in China. The development of therapeutic drugs is the current research focus. Dai-Bai-Jie is a traditional medicine of the Dai nationality, which is commonly used in the treatment of decreasing swelling, alleviating pain and detoxification. Most of the current researches focused on the component analysis of Dai-Bai-Jie, but few researches studied on its antitumor and pharmacological effect. In this study, we incubated A549 cells with different concentrations of Dai-Bai-Jie. The cell proliferation experiment showed that the DaiBai-Jie solution inhibited the proliferation of A549 cells and caused cell apoptosis. In this work, we confirmed that Dai-Bai-Jie had an inhibitory effect on the proliferation and migration of non-small cell lung cancer A549, which may be used as a novel candidate of anti-tumor therapy for lung cancer patients.
This article describes a fast and simple electrochemical assay for detecting cell concentration. After cell death, the membrane of cells will be broken, and DNA molecules contained in the cells will be released, but this does not happen in living cells. Sodium molybdate can react with the phosphate backbone of the released DNA molecules to form phosphomolybdate precipitation and produces a corresponding redox current. The higher the concentration of DNA, the stronger the intensity of the current generated. Sodium molybdate solution and centrifuged cell supernatant were added onto the glassy carbon electrode to determine the cell concentration by measuring the current intensity. The cell viability, which means the ratio of living cells to the total cells, can also be determined by this method. This assay has the advantages of high sensitivity, low detection limit, and wide detection range. In addition, this method was successfully applied to the detection of cell concentration in human serum, which has potential clinical applications.
A ratiometric fluorescent hybrid nanoprobe CDs-1 for arginine (Arg), exhibiting high sensitivity (the limit of detection, LOD, being 6.5×10-8 mol/L) and excellent selectivity and anti-interference ability, was fabricated through fluorescence resonance energy transfer (FRET) and the electrostatic attraction between positively-charged hemicyanine molecules and negatively-charged carbon dots (CDs). Arg can be quantitatively detected in the concentration range from 6.0×10-5 mol/L to 2.7×10-4 mol/L. Further, due to its ability to target mitochondrion and low cytotoxicity, intracellular Arg was successfully tracked through ratiometric fluorescence imaging.
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
