Latest ArticlesHerein we wish to propose the concept of "element-transfer reaction", which may afford the access to elemental compounds by transferring certain elements from easily available resources efficiently, concisely and precisely. A good element-transfer reaction with industrial application potential shall not generate waste and is performed under energy-saving and environment-friendly conditions. During the past decade, we have developed a series of methods for the synthesis of fluorine-and seleniumcontaining compounds via the fluorine-and selenium-transfer reactions, while the redox reactions were considered to be the oxygen-and hydrogen-transfer reactions as well and were also widely studied by our group for producing the high-value-added fine chemicals. Some of these technologies have been successfully industrialized. This review summarizes our staged research results on fluorine-, oxygen-, hydrogen-and selenium-transfer reactions and makes a prospect on the developing trend in the field.
In the past decade, nanoscale metal-organic frameworks (nMOFs) have drawn a great attention due to their high porosity, wide range of pore shapes, tunable frameworks and relatively low toxic. With the development of nanotechnology, many researchers studied the synthesis, characterization, functionalization and biotoxicity of nMOFs, and a more thorough understanding was developed about numerous nMOFs as promising platforms for biomedical applications. This review highlights the up-to-date progress of nMOFs related to their bio-applications such as drug delivery, bioimaging, biosensing and biocatalysis, and the common surface modification methods were classified into four categories:covalent post-synthetically modification, coordinative post-synthetically modification, noncovalent postsynthetically modification and modification on the external surface. At the same time, the challenges and perspectives of nMOFs were discussed as well.
(±)-Magoilgomer A[(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (-)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism (ECD) calculations. 2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury.
Near-infrared (NIR) light-triggered photothermal therapy (PTT) is a promising treatment strategy for treating cancer. The combination of nanotechnology and NIR has been widely applied. However, the therapeutic efficacy of the drug-delivery system depends on their ability to avoid phagocytosis of endothelial system, cross the biological barriers, prolong circulation life, localize and rapidly release the therapeutic at target sites. In this work, we designed a platelet membrane (PM)-camouflaged hollow mesoporous bismuth selenide nanoparticles (BS NPs) loading with indocyanine green (ICG) (PM@BS-ICG NPs) to achieve the above advantages. PM-coating has active tumor-targeting ability which could prevent drug leakage and provide drug long circulation, causing drug delivery systems to accumulate in tumor sites effectively. Moreover, as a type of the photothermal sensitizers, BS NPs are used as the inner cores to improve ICG stability and are served as scaffolds to enhance the hardness of this drug delivery system. For one hand, the thermal vibration of BS NPs under NIR laser irradiation causes tumor inhibition through hyperthermia. For another hand, this hyperthermia process could damage PM and let ICG rapid release from PM@BS-ICG NPs. The in vitro and in vivo results showed that this biomimetic nano-drug delivery system exhibits obvious antitumor activity which has good application prospect.
Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride (H-Leu-OMe HCl). LMSNs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, and small-angle X-ray diffraction (SAXRD), demonstrating a well-ordered mesostructure. After loading doxorubicin hydrochloride (Dox) into pores, considerable loading capacity of 30.5% and favorable cumulative release amount were obtained. MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor. The use of MSNs with the synthesized template, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.
Infectious diseases have always been a major cause of mobility and mortality, early and accurate diagnosis is important for their management. However, current clinical diagnosis for bacterial infection still remains troublesome. Recently, many attempts on molecular imaging have been made for prompt bacteria detection, especially for early and precise disease diagnosis. Among them, maltohexaose-based probes serve as a superb candidate due to the bacteria-specific maltodextrin transport pathway. These probes can visualize bacterial foci with unparalleled sensitivity and specificity. Such metabolism-based targeting strategy offers a powerful delivery platform for imaging and theranostic agents, providing good translational potential for developing antibacterial agents.
Herein, we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled by β-cyclodextrin (β-CD) based host-guest recognitions. This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma, suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier. The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens.
Inflammation, as the pathophysiological response of body to harmful stimuli, leads to changes in cellular microenvironment. To research pH changes in lysosomes of macrophages during inflammation, we designed a FRET (Förster resonance energy transfer) based probe, BDP-RhB. The probe showed good lysosome targeting ability, wide response range of pH from 8.0 to 4.0 with significant ratio (I582/I518) change from 0.6 to 3.4, and good reversibility and sustainability. By applying BDP-RhB, we found a decrease of lysosomal pH of macrophages during inflammation.
To overcome the shortcomings of single component carrier supported platinum (Pt)-based catalysts, herein, we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based catalysts. The alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum source. Further, the effect of alumina content on the properties of the composites is investigated. The composites and catalysts are characterized by using XRD, XPS, N2 sorption, and TEM. The Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina, pore diameter, and moderate Pt nanoparticle size, resulted in 99.5% of conversion efficiency and 77.4% of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate (EOPB). Interestingly, this composite can be used more than 20 times without a significant decrease in its performance.
The copper-catalyzed directed dearomatization of indoles with the assistance of directing groups has been developed for the synthesis of 2, 3-diazido indolines with good yields and excellent diastereoselectivities in aqueous solution. The resultant 2, 3-diazides can be smoothly converted to other functional groups, including vicinal diamines, triazoles and benzotriazoles, in a single step.
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