Latest Articles(±)-Magoilgomer A[(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (-)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism (ECD) calculations. 2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury.
Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride (H-Leu-OMe HCl). LMSNs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, and small-angle X-ray diffraction (SAXRD), demonstrating a well-ordered mesostructure. After loading doxorubicin hydrochloride (Dox) into pores, considerable loading capacity of 30.5% and favorable cumulative release amount were obtained. MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor. The use of MSNs with the synthesized template, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.
In the past decade, nanoscale metal-organic frameworks (nMOFs) have drawn a great attention due to their high porosity, wide range of pore shapes, tunable frameworks and relatively low toxic. With the development of nanotechnology, many researchers studied the synthesis, characterization, functionalization and biotoxicity of nMOFs, and a more thorough understanding was developed about numerous nMOFs as promising platforms for biomedical applications. This review highlights the up-to-date progress of nMOFs related to their bio-applications such as drug delivery, bioimaging, biosensing and biocatalysis, and the common surface modification methods were classified into four categories:covalent post-synthetically modification, coordinative post-synthetically modification, noncovalent postsynthetically modification and modification on the external surface. At the same time, the challenges and perspectives of nMOFs were discussed as well.
MnS as anode material for sodium-ion batteries (SIBs) has recently attracted great attention because of the high theoretical capacity, great natural abundance, and low cost. However, it suffers from inferior electrical conductivity and large volume expansion during the charge/discharge process, leading to tremendous damage of electrodes and subsequently fast capacity fading. To mitigate these issues, herein, a three-dimensional (3D) interlaced carbon nanotubes (CNTs) threaded into or between MnS hollow microspheres (hollow MnS/CNTs composite) has been designed and synthesized as an enhanced anode material. It can effectively improve the electrical conductivity, buffer the volume change, and maintain the integrity of the electrode during the charging and discharging process based on the synergistic interaction and the integrative structure. Therefore, when evaluated as anode for SIBs, the hollow MnS/CNTs electrode displays enhanced reversible capacity (275 mAh/g at 100 mA/g after 100 cycles), which is much better than that of pure MnS electrode (25 mAh/g at 100 mA/g after 100 cycles) prepared without the addition of CNTs. Even increasing the current density to 500 mA/g, the hollow MnS/CNTs electrode still delivers a five times higher reversible capacity than that of the pure MnS electrode. The rate performance of the hollow MnS/CNTs electrode is also superior to that of pure MnS electrode at various current densities from 50 mA/g to 1000 mA/g.
Dracomolphesin A-E (1-5), five 3, 4-seco-phenylpropanoids featuring an aromatic ring opened framework, were isolated from the aerial parts of Dracocephalum moldavica. The structures with absolute configurations were determined by spectroscopic methods coupled with Mosher method. Notably, these compounds represented an example of aromatic ring cleavage products of phenylpropanoids. The possible biosynthetic pathway of these compounds was proposed. Compounds 1, 2, 4 and 5 were demonstrated to be Nrf2 pathway activators.
Au or other metal nanostructures have the ability to strongly quench the fluorescence of fluorophores. This feature has made AuNP-conjugates attractive for the construction of platforms for various bioanalytes to overcome the limitations of small molecule fluorophores (poor solubility, long reaction time). In this paper, an ultrafast "Turn-On" fluorescent sensor for biothiols was constructed. The sensor is based on the fluorescent resonance energy transfer (FRET) effect between the fluorophore (PN) and AuNPs, which effectively quenches the fluorescence of the fluorophore. In the presence of thiols, PN is displaced and released from AuNP surfaces, and thus, the fluorescence is rapidly restored. The sensor features appreciable water solubility and ultrafast response time (a few seconds for Cys). In addition, it exhibits high selectivity and a detection limit as low as 12 nmol/L for Hcy. Moreover, the sensor presents good biocompatibility and has been successfully applied for imaging biothiols in living cells.
Non-nerve cell-derived extracellular matrix (ECM) was coated on the aligned porous polypyrrole-poly(L-lactide) (PPy-PLLA) fiber-films with the conductivity of ~12 mS/m via L929 cells culture and lysing, resulting in~10% increase of PC12 cells attachment and 26 μm increase of neurites length. The neurite length of ~149 μm in EGF/NGF group (optimal concentration radio of 12.5/50 (ng/mL)) on aligned and ECM-conjugated fiber-films was significantly larger than ~94 μm in only NGF group (50 ng/mL), confirming the synergy of EGF, NGF and aligned ECM-conjuaged PPy-PLLA fibers. When differentiated PC12 cells were exerted electrical stimulation (ES) of 100 mV/cm for 4 h/day in 2 day through ECM-PPyPLLA fiber-films, their neurite length reached to ~251 μm, significantly larger than ~149 μm of group without ES, due to the higer expression of related neural proteins in ES group. A simple mechanism was proposed to analyze synergistical effect of ECM, EGF, NGF on axons adhesion and elongation along the aligned ECM-coated fibers under ES condition.
Herein, a WO3-CuWO4 nanostructured heterojunction was prepared by a facile two-step hydrothermal method. It is composed of a WO3 square microplate and CuWO4 nanoparticles. Then, the gas sensing properties were investigated under optimal operating temperature (120 ℃). The WO3-CuWO4 heterostructure shows good sensing performance towards n-butanol, with a response value up to 9.4 to towards 30 ppm n-butanol, and the response value is about 3 times higher than that of pristine WO3. Its detection limit for n-butanol is 0.1 ppm, which indicates a potential application in lower concentration detection. Moreover, the response time of WO3-CuWO4 nanostructured heterojunction and the pristine WO3 are 21 s and 240 s respectively, revealing that there is a faster gas sensing process in the heterostructure. A possible sensing mechanism was then proposed on the basis of experimental data and band structure analysis. The significant enhancement of WO3-CuWO4 heterostructure could be attributed to the formation of heterojunction, which brings electronic sensitization and electron transport pathway modulation. The work offered a kind of novel and cost-effective sensing materials, and inspired more novel devices based on nanostructured heterojunction mechanism.
A series of novel 1, 2, 4-oxadiazole-containing N-pyridylpyrazole derivatives 12a-h were efficiently synthesized with pivaldehyde, pyridylpyrazole carboxylic acid and arylamine as raw materials via 1, 3-dipolar cycloaddition. Their structures were identified by melting points, 1H NMR, 13C NMR and elemental analysis or HRMS. The exploration on the single-crystal structures of 12c and 12g revealed the stereochemical and substituent oriental characteristics, and the relevance of the structure and the reaction activity of this type of compounds. The preliminary bioassays indicated that several compounds had good insecticidal activities, among which 12c showed a lethality rate of 80% towards Mythimna separata Walker at 200 μg/mL; some of the compounds exhibited favorable fungicidal activities at 50 μg/mL against Physalospora piricola, Rhizoctonia cereal, Sclerotinia sclerotiorum, etc. Among which, 12a, 12b, 12c and 12h could be considered as new fungicidal leading compounds for further structural optimization. These discoveries along with the structure-activity relationship analysis in this paper will provide useful guidance for the innovative studies on new pyridylpyrazole derivatives and their applications in agrochemical area.
The exploitation of multifunctional nanocomposites is highly desired in environmental monitoring, biosensors, and medical diagnosis. In this paper, a simple approach has been proposed to fabricate MoS2 decorated N-doped carbon nanotubes (NCNTs@MoS2) hybrid composites as efficient peroxidase-like mimics. The combination of the MoS2 and N-doped carbon nanotubes (NCNTs) brings about an enhanced synergistic effect, leading to remarkably decent intrinsic peroxidase-mimic activities than that of the single components. Due to the high catalytic efficiency of the resultant NCNTs@MoS2 hybrid nanotubes as peroxidase-like mimics, a convenient colorimetric approach for the sensitive determination of H2O2 and ascorbic acid have been developed with a detection limit of about 0.14 μmol/L and 0.12 μmol/L, respectively. The work offers a new strategy for the fabrication of peroxidase-like nanomaterials with excellent catalytic activity, which indicates great promising applications in sensitive detections in real samples.
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