Latest ArticlesRapid detection and identification of Escherichia coli (E. coli) is essential to prevent its quickly spread. In this study, a novel fluorescence probe based on ZnTe quantum dots (QDs) modified by mannose (MAN) had been prepared for the determination of E. coli. The results showed that the obtained QDs showed excellent selectivity toward E. coli, and presented a good linearity in range of 1.0×105~1.0×108 CFU/mL. The optimum fluorescence intensity for detecting E. coli was found to be at pH 7.0 with a temperature of 25 ℃ and incubation time of 20 min. Under these optimum conditions, the detection limit of E. coli was 4.6×104 CFU/mL. The quenching was discussed to be a static quenching procedure, which was proved by the quenching efficiency of QDs decreased with the temperature increasing.
Recent days, aggregatable nanoparticles, which can specifically respond to certain stimulus, have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper penetration. In this review, we summarize recent advances in design of aggregatable nanoparticles by different stimuli. Internal (pH and enzyme) and external (light, temperature and ROS) stimuli are introduced for a comprehensive description. Moreover, the aggregated nanoparticles usually exhibit photothermal, photoacoustic, PET and enhanced MRI contrast, which is also described. In the end, we discuss about the potential applications and challenges for the future clinical translation.
A systematic spectral analysis was presented for bishemicyanine dyes (Hsd and D2) and monohemicyanine dyes (Hs and DSMI). The bishemicyanine dyes displayed long emission wavelengths, large Stokes shifts, low background quantum yields in aqueous solutions and high sensitivity in viscous environments. Better understanding of the structure-property relationships could benefit the design of improved dyes. Computational studies on these dyes revealed the three conjugated forms of bishemicyanines are in equilibrium due to two positive charges and a branched bulk substituent. Bishemicyanines possessed obviously lower rotating energy barrier of C-C bond rotation compared to the monohemicyanine dyes. Moreover, the synergetic effects of the rotation about the ϕ4 bond, ϕ5 bond and ϕ7 bond of the bishemicyanines (Hsd and D2) lead to lower fluorescence quantum yields in a free state and larger fluorescence quantum yield enhancements in viscous environment compared to that of monohemicyanine dyes (Hs and DSMI). The results demonstrate a foundation for interpretation of the behavior of the dyes, thus providing guidelines for future of new bishemicyanine fluorophores with specific applications.
Semitransparent organic solar cells (ST-OSCs) have the potentials to open promising applications that differ from those of conventional inorganic ones, such as see-through power windows with both energy generation and heat insulation functions. However, to achieve so, there remain significant challenges, especially for balancing critical parameters, such as power conversion efficiency (PCE), average visible transparency (AVT) and low energy infrared photon radiation rejection (IRR) to realize the full potentials of ST-OSCs. Herein, we demonstrate the new design of ST-OSCs through the rational integration of organic materials, transparent electrode and infrared photon reflector in one device. With the assistance of optical simulation, new ST-OSCs with precise layout exhibit state-of-art performance, with near 30% AVT and PCE of 7.3%, as well as an excellent IRR of over 93% (780-2500 nm), representing one of best multifunctional ST-OSCs with promising perspective for window application.
Two-dimensional (2D) heterostructural Ni2P/rGO is successfully fabricated by in-situ phosphating selfassembled NiO/rGO composites and shows the enhanced electrochemical performances. In this design, the rGO sheets effectively reduce the lattice strain created during the phase transformation from NiO to Ni2P, thereby maintaining ultrathin nanostructures of Ni2P. The resulting Ni2P/rGO layered heterostructure gives the composite plenty of pores or channels, good electrical conductivity and well-exposed active sites. Density functional theory (DFT) calculation further demonstrates that the Fermi energy level and electron localize of near Ni atoms in Ni2P is higher than that of NiO, which endow Ni2P with faster and more reversible redox reactivity in dynamic. Benefiting from their structural and compositional merits, the as-synthesized Ni2P/rGO exhibits high specific discharge capacity and excellent rate performance. Furthermore, a hybrid supercapacitor built with Ni2P/rGO and activated carbon shows a high specific energy of 38. 6 Wh/kg at specific power of 375 W/kg.
Since the discovery of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the process of municipal solid waste incineration (MSWI), a large number of researches have been conducted to reveal their formation mechanisms and emission characteristics. As one of national priority control pollutants, chlorinated organics are inclined to transfer into PCDD/Fs in the heterogeneously catalyzed process, which has been considered to be one of great challenges in environmental catalysis. However, so far direct evidences to support such a conversion process are insufficient, and the reaction mechanisms are lack of exploration. This study investigated the catalytic elimination of chlorobenzene (CBz) over a range of industrially applied active species including Pt, Ru, V, Ce and Mn oxides, and explored their reaction byproducts, chlorine adsorption/desorption behaviors and PCDD/F formations. We found that all of these species could generate the PCDD/Fs, amongst which, Mn species were the most active for PCDD/F formation. Approximately 140 ng I-TEQ g-1 PCDD/Fs were detected on the Mn-CNTsurface after ageing at 250 ℃ for 30 h. Even using the dichloromethane (DCM) as a precursor, significant PCDD/Fs were still detected. The Ru and V species were shown to generate much less polychlorinated byproducts and PCDD/Fs, owning to their sufficiently high abilities in Cl desorption, which were through the semi-Deacon and Brønsted H reactions, respectively.
Highly active and stable magnetic copper catalysts were successfully achieved by magnetic induced Stöber method and subsequent hydrothermal reaction with copper ions in alkaline condition. The high content of Cu2+ as well as the unique structures of hierarchical copper silicate in the as-prepared catalysts endowed their outstanding catalytic performance. Efficient decarboxylative A3-coupling of α-keto acid, amine and alkyne was realized with the low Fe3O4@CuSiO3 loading. A range of propargylamines were produced in good to excellent yields under solvent-free condition. Moreover, the catalyst can be easily separated from the final organic product with an external magnet. Also, this kind of catalyst could be recycled up to six times while maintaining its activity.
Described here is the first example of Cu(0)-catalyzed intramolecular decarbonylative rearrangements of readily available N-aryl isatins assisted by solvent dimethyl sulfoxide (DMSO) under air atmosphere and additive-free conditions leading to various biologically important acridones in good to excellent yields. This novel transformation is proposed to go through a sequential DMSO-aided Cu insertion into the amide C—N bond, CO extrusion, Cu migration, reductive elimination and DMSO-aided proton migration processes, involving multiple types of bond cleavage and formation in a single chemical step.
Surgical suture is commonly used in clinic due to its action in accelerating the process of wound healing. However, difficultly handling in minimally invasive surgery and bacteria-induced infection usually limit its use in a wide range of applications. Here, we report a facile scalable strategy to fabricate surgical sutures with shape memory function and antibacterial activity for wound healing. Specifically, a shape memory polyurethane (SMPU) with a transition temperature (Ttrans) at 41.3 ℃ was synthesized by adjusting the mole ratio of the hard/soft segment, and then the shape memory surgical sutures containing polyhexamethylene biguanide hydrochloride (PHMB) as a model drug for antibacterial activity were fabricated by a facile scalable one-step wet-spinning approach, in which PHMB was directly dissolved in the coagulation bath that enable its loading into the sutures through the dual diffusion during the phase separation. The prepared sutures were characterized by their morphology, mechanical properties, shape memory, antibacterial activity, as well as biocompatibility before the wound healing capability was tested in a mouse skin suture-wound model. It was demonstrated that the optimized suture is capable of both shape memory function and antibacterial activity, and promote wound healing, suggesting that the facile scalable one-step wet-spinning strategy provides a promising tool to fabricate surgical sutures for wound healing.
Transcatheter hepatic artery chemoembolization (TACE) is a universal treatment for patients with hepatocellular carcinoma (HCC) that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics locally to the tumor. The strategy of combining TACE formulation with image-guided ablation holds tremendous potential, but patient tolerance and undesired toxicity/immunosuppression remains a challenge. The application of nanotechnology in TACE opens new doors for the treatment of HCC. Strikingly, nanomaterials or nano-drugs dispersed in the TACE formulation can effectively improve the delivery efficiency of drugs by achieving both controlled and continuous release. In addition, the utilization of multifunctional nanoparticles can provide guidance and monitoring for various advanced imaging methods for TACE treatment, and can realize the combination therapy of thermal ablation, microwave ablation, in situ radiotherapy, and other therapies, greatly expanding the therapeutic strategies available for HCC treatment. Here, the current exploration of nanotechnology in TACE of HCC is briefly summarized and the challenges of TACE with nanoformulations for clinical translation are comprehensively discussed.
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
