Latest ArticlesAn efficient protocol for the synthesis of asymmetric 1, 3-diketones was reported through diacylation of 1, 1-diborylalkanes using two different acyl sources. In this transformation, an enolate boron species was initially formed by introducing an acyl group, then it was trapped by another acyl group to form 1, 3-diketone. This method not only provided the gateway to obtain a series of 1, 3-diketones, but also afforded an operationally simple and efficient access to pyrazoles and isoxazoles.
A TFA promoted multi-component reaction of aryldiazonium with sodium metabisulphite and thiols to construct thiosulfonates under transition-metal free conditions is reported. The thiosulfonates were isolated in good yields with broad tolerance of functional group. Readily available inorganic Na2S2O5 was applied as the sulfur dioxide surrogate. This strategy features easily available substrates, mild reaction conditions and free transition-metal catalyst.
Protein-metabolite interactions (PMIs) play important roles in various biological processes, especially in disease progression. However, due to the complexity of living cells, it is very difficult to identify specific PMIs. Herein, we chose one oncogenic factor, metadherin (MTDH), as a bait to identify its in vivo interacting metabolites in cancer cells. Cholesterol is an important metabolite and essential structural component of cell membranes. It could also drive several diseases including cancer. Interestingly, we found that cholesterol robustly interacted with MTDH and downregulated the expression of MTDH in cancer cells. Furthermore, MTDH disturbed metabolite alterations under cholesterol treatment in MTDH transduced cancer cells. Collectively, our results uncover an undescribed PMI where MTDH, as an oncogenic factor, might positively regulate cancer progression by interacting with cholesterol. This study interprets the theoretical basis of PMI-oriented cancer progression and targeting therapies in clinic.
Manganese-catalyzed hydrogenation of unsaturated molecules has made tremendous progresses recently benefiting from non-innocent pincer or bidentate ligands for manganese. Herein, we describe the hydrogenation of quinolines and imines catalyzed by simple manganese carbonyls, Mn2(CO)10 or MnBr(CO)5, thus eliminating the prerequisite pincer-type or bidentate ligands.
Rh/ZhaoPhos-catalyzed asymmetric hydrogenation of a series of (E)-2-(chroman-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities (up to 99% yield, 98% ee). Moreover, the gram-scale hydrogenation could be performed well in the presence of 0.02 mol% catalyst loading (TON = 5000), the hydrogenation product was easily converted to access other important compounds, which demonstrated the synthetic utility of this asymmetric catalytic methodology.
Hyperbranched polymers have attracted increasing interests due to their unique structure-related advantages and have been utilized as drug carriers for controlled delivery. However, it is still challenging to prepare multi stimuli-responsive hyperbranched polymers to sense and response the complex yet delicate changes in physiological environment. Herein, we propose a triple-stimuli backbone-breakable hyperbranched polymer (HBP(OEG-IB)), which is prepared via the convenient iminoboronate multicomponent reaction of α, w-di(1, 2-diol)s oligo(ethylene glycol), tris(3-aminopropyl)amine and 2-formylphenylboronic acid. Upon the stimulation of CO2, lactic acid and glutathione, micelles formed by HBP(OEG-IB) could be disrupted via the dissociation of iminoboronate ester bond to subsequent release incorporated camptothecin (CPT). Cell experiments show that the HBP(OEG-IB) is non-toxic but can enhance the therapeutic effect of CPT thanks to the effect of the protonated tertiary amino groups. The demonstration made in this work can enrich the design of responsive HBPs and can be readily applied to other systems with tunable responsive properties and functions.
Although occupying pillar position in clinical cancer treatments, surgery itself and surgical trauma would elicit series of local/systemic inflammation-related responses that resulted in high rate of tumor recurrence. Herein, chitosan with conjugated gallic acid (CSG) molecules were coordinated with Fe3+ to form CSG/Fe3+ hydrogel for filling the tumor-resected cavity with considerable wet-adhesion ability and anti-inflammatory performance. With the assistance of doxorubicin hydrochloride (DOX·HCl), CSG/Fe3+/DOX hydrogel exhibited synergistic photothermal-chemo tumor-inhibited performance under near-infrared (NIR) light irradiation for eradicating residual and/or surgical trauma-recruited cancer cells. Thus, our study attempts to show a paradigm that realizes quick surgical trauma healing, inflammation inhibition and prevention of postsurgical tumor recurrence.
Se/C as a novel carbon-based biomaterial was prepared by using cheap and abundant glucose as the carbon source. It was highly active and could well restrain Xanthomonas campestris pv. campestris (EC50 = 4.7403 μg/mL), a very harmful germ causing the devastating cabbage black rot disease and resulting in huge economic losses. As a type of carbon material insoluble in water, Se/C is bio-compatible and can adhere onto the leaves of the plants to allow a slow and sustained release of its efficacy, affording an efficient method for the cabbage black rot disease prevention and cure. This work as the first report on the bioactivity studies of Se/C significantly expands the application scopes of the selenium-containing materials and may draw continuous attentions from a broad field.
Semiconductor-based photoelectrocatalytic processes have attracted considerable research interest for solar energy collection and storage. Photoelectrocatalysis is a heterogeneous photocatalytic process in which a bias potential is applied to a photoelectrode, and thus the photoelectrocatalytic performance is closely related to the photoelectrode prepared by semiconductors. Among various semiconductors, metal-organic frameworks (MOFs) have attracted more and more attention because of their unique properties such as optical properties and adjustable structure. Herein, a comprehensive review on different MOFs (Ti-based, Zn-based, Co-based, Fe-based, Cu-based, and mixed metal-based MOFs) for heterogeneous photoelectrocatalysis is carried out and, in particular, the application of this technique for CO2 conversion and water splitting is discussed. In addition, the challenges and development prospects of MOFs in photoelectrocatalysis are also presented.
Accurate temperature measurement plays an important role in a variety of industrial processes and scientific researches. In our work, the dual-mode temperature response nanoprobe CDs-Tb-TMPDPA containing a two-photon ligand (4-(2, 4, 6-trimethoxyphenyl)-pyridine-2, 6-dicarboxylic acid, TMPDPA) sensitized Tb3+ as a temperature-sensitive unit and carbon dots (CDs) as photothermal reagent and a fluorescence reference unit, have been designed and synthesized. In this system, both the fluorescence intensity ratio and the fluorescence lifetime have a good response to temperature. In addition, due to the excellent photothermal conversion capability of CDs, photothermal antibacterial ability was also tested. Based on the temperature dependence of the fluorescence and the two-photon excitation characteristics of CDs-Tb-TMPDPA, the nanoprobe can also be used in the anti-counterfeiting. Our finding opens a new prospect for the use of two-photon sensitized dual-mode fluorescence thermometers.
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