Latest ArticlesAtherosclerosis is a persistent inflammatory state, while vascular endothelial fibrosis is one of the primary causes of atherosclerosis development. Although ligustilide (Lig) was shown to exert obvious antiatherogenic effects in previous studies, its precise mechanism has not been deeply discussed. In this paper, we designed a Lig-derived photoaffinity labelling (PAL) probe to identify potential therapeutic targets of Lig via chemical proteomics approach. Mothers against decapentaplegic homologue 3 (SMAD3), a signal transmitter of transforming growth factor-β (TGF-β) which promotes the development of vascular fibrosis, was identified as a potential target of Lig. Lig suppressed the phosphorylation and nuclear translocation of SMAD3 by blocking the interaction between SMAD3 and TGF-β receptor 1, thereby inhibiting the collagen synthesis process. Hence, developing a novel SMAD3 inhibitor may present a promising therapeutic option for preventing vascular fibrosis.
Both nitrogen-doping feature and pore structure are critical factors for developing nitrogen-doped carbons based catalysts with a high performance toward oxygen reduction reaction (ORR). Herein, a simple one-step CVD of acetylene and acetonitrile vapor method using silanized SBA-15 as a template has been developed to synthesize an ordered porous carbon (OPC) with dual nitrogen-doped interfaces. The optimized sample as prepared with the CVD of 4 h at 750 ℃ contains two types of ordered mesopores that one type is the ordered cylindrical pores inheriting from the pores of SBA-15 and has a pore width of 4.0~5.0 nm, the other type is the ordered quasi-hexagonal pores with a width of 3.0~4.0 nm produced by etching the pore walls of SBA-15. These two types of pores whose pore walls are built by the nitrogen doped carbon layers resulted by the CVD and thus it actually makes the dual nitrogen-doped interfaced OPC (DN-OPC). Meanwhile, DN-OPC contains a few of micropores and a large SSA of 1430 m2/g. This dual-ordered pores and dual nitrogen-doped interfaces cannot only facilitate mass transport but also utilize the active sites of DN-OPC for ORR. Therefore, as metal-free ORR catalyst, DN-OPC exhibits a good activity close to commercial Pt/C catalyst, and an excellent durability and methanol tolerance.
Corneal neovascularization (CNV) can induce severe visual impairment and even blindness. Current treatments have limited efficacy and some undesirable side effects. Phototherapy (PT) is a modern medical technique in CNV treatment and worth further improvement. Nanotechnology has various advantages and nanoparticle-mediated drug delivery also contributes to CNV elimination. Phototherapy combined with functional nanoparticles featuring photoacoustic imaging contrast properties can accomplish accurate and safe inhibition of CNV, thus is promising in clinical application.
A pyrene-tiaraed pillar[5]arene derivative was synthesized, which showed a concentration-independent intensive excimer emission. Photolysis of the pyrene-tiaraed pillar[5]arene led to a switch from excimer to monomer emission, applicable to photo-writing.
Incorporation of heteroatoms into the framework of zeolites has become a significant strategy to improve their performance in catalysis and adsorption, because the obtained heteroatom zeolites exhibit quite different properties from the conventional aluminosilicate zeolites in aspects of surface acidity, pore structures, particle size and so on. In this review, the progress on the heteroatom zeolites including their synthesis and application is highlighted. First, the recent advance on the design and synthesis of different heteroatom zeolites is summarized. Special emphasis is placed on the introduction and comparison of three typical methods, including the direct synthesis, post synthesis and improved direct synthesis, for the traditional heteroatom zeolites (such as TS-1, Sn-MFI, Sn-β) and newly-reported heteroatom zeolites (such as W-MFI, Mo-MFI). According to their intrinsic characteristics, the application of heteroatom zeolites in diverse fields, such as production of fine chemicals, air pollution control and biomass conversion is then discussed. Finally, the challenges and perspective on the future development of heteroatom zeolites in low-cost preparation and practical application are proposed.
A high efficiency and low toxicity radiosensitizer, OsN(PhenOH)Cl3, was designed and synthesized through substituent regulation. To the best of our knowledge, this is the first osmium-based coordination complex radiosensitizer. The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.
In this study, a promising strategy has been developed to promote bone regeneration by combining antioxidant activities and osteoimmunomodulatory properties. Herein, an L-arginine/nanofish bone (Arg/NFB) nanocomplex has been prepared and evaluated in vitro and in vivo. The Arg/NFB nanocomplex possesses good antioxidant activities and could modulate the polarization of non-activated macrophage into different types and induce the secretion of pre-inflammatory, anti-inflammatory, osteogenic as well as angiogenic cytokines. Additionally, the regulated immune microenvironment can enhance the osteogenic differentiation of mouse embryo osteoblast precursor cells (MC3T3-E1) and angiogenic capacity of human umbilical vein endothelial cells (HUVECs), leading to the improved formation of mineralized nodules, alkaline phosphatase activity and angiogenic effects. In vivo results with cranial defect models reveal that the treatment of Arg/NFB nanocomplex exhibited significant improvement of new bone formation and angiogenesis. All the results demonstrate Arg/NFB nanocomplex with antioxidant activities and osteoimmunomodulatory properties could be a new idea for developing the next generation of bone regeneration biomaterials.
Cyclodextrin (CD) has special spatial structure and well biological safety, so it has been widely used for constructing CD-based nanoplatforms. Through functionalization, cyclodextrin can form various stimulus-response nanoplatforms, such as pH, temperature, redox, light and magnetic fields. In this study, we designed a highly sensitive reactive oxygen species (ROS)-responsive polymer PCP which encapsulated doxorubicin (DOX) and purpurin 18 (P18) to achieve the synergy of photodynamic and chemotherapy. The high content of reactive oxygen species(ROS) in the tumor microenvironment(TME) triggers the cleavage of the borate bond of MPEG-CD-PHB(PCP), thereby promoting the release of drugs.When irradiated with near-infrared laser, the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis. Compared with monotherapy, a series of experiments confirmed that our micelles had enhanced anti-cancer activity. This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy.
Cobalt phosphide (CoP) is a promising anode candidate for lithium-ion batteries (LIBs) due to its high specific capacity and low working potential. However, the poor cycling stability and rate performance, caused by low electrical conductivity and huge volume variation, impede the further practical application of CoP anode materials. Herein, we report an integrated binder-free electrode featuring needle-like CoP arrays grown on carbon fiber cloth (CC) for efficient lithium storage. The as-prepared CoP/CC electrode integrates the advantages of 1D needle-like CoP arrays for efficient electrolyte wettability and fast charge transportation, and 3D CC substrate for superior mechanical stability, flexibility and high conductivity. As a result, the CoP/CC electrode delivers an initial specific capacity of 1283 mAh/g and initial Coulombic effeciencies of 85.4%, which are much higher than that of conventional CoP electrode. Notably, the CoP/CC electrode shows outstanding cycling performance up to 400 cycles at 0.5 A/cm2 and excellent rate performance with a discharge capacity of 549 mAh/g even at 5 A/cm2. This work demonstrates the great potential of integrated CoP/CC hybrid as efficient bind-free and freestanding electrode for LIBs and future flexible electronic devices.
(S, S)-Me-BI-DIME/Pd(0)-catalyzed ennantioselective C–H functionalization of N-ferrocenyl o-bromo-benzanilides has been realized, affording isoquinolinone-fused ferrocenes with up to 97% ee. The products can be transformed into planar chiral ferrocenyl monophosphines, which demonstrate their preliminary application.
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