Latest ArticlesAmmonium vanadate has been considered as a competitive high-performance cathode material for aqueous Zn-ion batteries. However, it still suffers from insufficient rate capability and poor cyclability due to the low electronic conductivity. Herein, (NH4)2V6O16·0.9H2O nanobelts with reduced graphene oxide (RGO) modification are synthesized by one-step hydrothermal reaction. Benefiting from the addition of RGO, an excellent electrochemical performance of (NH4)2V6O16·0.9H2O@RGO nanobelts can be obtained. The (NH4)2V6O16·0.9H2O@RGO displays a high-rate capacity and a high energy density of 386 Wh/kg at 72 W/kg. In particular, after 1000 cycles at 5 A/g, the capacity remains at 322 mAh/g with 92.8% capacity retention. In addition, the key reaction mechanisms of reversible Zn2+insertion/extraction in (NH4)2V6O16·0.9H2O@RGO are clarified.
The design of assembling high-nuclearity transition-lanthanide (3d-4f) clusters along with excellent magnetocaloric effect (MCE) is one of the most prominent fields but is extremely challenging. Herein, two heterometallic metal coordination polymers are constructed via the "carbonate-template" method, formulated as {[Gd18Ni24(IDA)22(CO3)7(μ3-OH)32(μ2-OH)3(H2O)5Cl]·Cl8·(H2O)14}n and {[Eu18Ni23.5(IDA)22(CO3)7(μ3-OH)32(H2O)5(IN)(CH3COO)2(NH2CH2COO)Cl]·Cl6·(H2O)17}n [abbreviated as 1-(Gd18Ni24)n and 2-(Eu18Ni23.5)n respectively; H2IDA = iminodiacetic acid; HIN = isonicotinic acid]. Concerning the structures, compounds 1-(Gd18Ni24)n and 2-(Eu18Ni23.5)n both feature the one-dimensional (1D) chain-like structure which is rarely reported in high-nuclearity metal complexes. Meanwhile, the large presences of Gd3+ ions in compound 1-(Gd18Ni24)n are conducive to the fantastic MCE, and the value of -∆Sm is 35.30 J kg-1 K-1 at 3.0 K and ∆H = 7.0 T. And more significantly, compound 1-(Gd18Ni24)n shows the large low-field magnetic entropy change (-∆Sm = 20.95 J kg-1 K-1 at 2.0 K and ∆H = 2.0 T) among the published 3d-4f mixed metal clusters.
A HAT based large PAH discotic molecule PN8 is developed. The enlarged chromophoric core and doping heteroatoms enable colorimetric and fluorometric sensing of Cu2+ and Zn2+ with highly appreciable optical changes, good selectivity and low detection limit. Moreover, PN8 was demonstrated as an excellent adsorbent to remove Cu2+ and Zn2+ from wastewater.
Thrombotic disease is a major problem that endangers human health. At present, MRI and CT are commonly used clinically to diagnose thrombosis, and thrombolytic drugs are used for treatment), but the diagnosis time is lagging, the utilization of drugs is low, and the resulting systemic toxicity problems such as side effects lead to poor treatment effects. Nanotechnology combining photoacoustic dynamics and chemical dynamics has shown great application value in tumor targeting, diagnosis, detection and treatment. It has also become a new direction in the diagnosis and treatment of thrombotic diseases, and has created new applications in the field of nanomaterials. This review summarizes the new progress of this combination in the diagnosis and treatment of thrombotic diseases according to the differences in the construction of the nanotherapy system, at the same time, we put forward some new problems and prospects for the integration of thrombosis diagnosis and treatment.
We report a series of highly stable metallophthalocyanine-based covalent organic frameworks (MPc-dx-COFs) linked by robust 1, 4-dioxin bonds constructed through nucleophilic aromatic substitution (SNAr) reaction. The chemical structures and crystallinity of the COFs largely remain unchanged even after treating with boiling water (90 ℃), concentrated acids (12 mol/L HCl) or bases (12 mol/L NaOH), oxidizing (30% H2O2) or reducing agents (1 mol/L NaBH4) for three days due to their stable M-Pc building blocks and resilient dioxin linkers. With metallated phthalocyanine active sites regularly arranged in the stable framework structures, MPc-dx-COFs can be directly used as efficient electrocatalysts for the oxygen reduction reaction (ORR) without pyrolysis treatment that has commonly been used in previous studies.
Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions (Ag+, Hg2+, Cu2+). The probe shows divergent fluorescence (FL) /circular dichroism (CD) responses via divergent bond-cleavage cascade reactions (metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL "turn-off" and CD "turn-on" for Ag+ (no hydrolysis), FL "turn-on" and CD "turn-off" for Hg2+ (imine hydrolysis), and FL "self-threshold ratiometric" and CD "turn-off" for excess Cu2+ (lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.
Using nanoparticle-based drug delivery systems as enhancers is a robust strategy for transdermal delivery; however, the mechanisms by which these systems promote transdermal penetration are still unclear. Here, we fabricated a dual-labeled nano drug delivery system that allows discrete visualization of both the drug and the nanoparticle carrier. To comprehensively examine its potential mechanism, we investigated its effects on human epidermal keratinocyte HaCaT cells, including changes in cell membrane potential, intracellular Ca2+ concentration, and Ca2+-ATPase activity. P-glycoprotein (P-gp) expression in nanoparticle-treated human dermal microvascular endothelial cells was detected by western blotting and immunofluorescence. Furthermore, the transdermal absorption and biodistribution of the dual-labeled nanoparticles were deeply investigated by skin permeability study in vitro and in vivo using fluorescence microscopy and in vivo imaging, respectively. In addition to reducing membrane potential, increasing the intracellular Ca2+ concentration, and decreasing Ca2+-ATPase activity, our results indicate that the dual-labeled nanoparticles can downregulate P-gp to promote transdermal absorption. Fluorescence and in vivo imaging visually demonstrated that the nanoparticle delivery system penetrated into the dermis through the stratum corneum. All these results indicate that this dual-labeled nano delivery system provides a new method for future in-depth visual explorations of transdermal drug delivery mechanisms.
Glutathione (GSH) plays a critical role in maintaining cellular redox homeostasis in biological system. Mitochondrion is a pivotal organelle for cellular aerobic respiration and its disorder is associated with impaired redox balance, leading to cell death. In this work, we designed and synthesized a non-invasive "off-on" mitochondrial-targeting fluorescent probe QZ for the detection of GSH in living cells. Based on the mechanism of native chemical ligation (NCL) and fluorescence resonance energy transfer (FRET), a rhodamine B derivative, QZ was prepared, by choosing aromatic thioester bond as the selective reaction site. QZ exhibited excellent detection capability for GSH over Cys and Hcy. Upon addition of GSH to QZ solution, a remarkably enhanced fluorescence was observed with a limit of detection of 2.98 μmol/L. Furthermore, QZ was found to possess the specific mitochondrial localization ability in cell imaging experiments. Moreover, with exogenous and endogenous stimulations, QZ could image GSH in living cells.
We report a facile and tailored method to prepare globally twisted chiral molecular cages through tunable coordination of bis-bipyridine-terminated helicene ligands to a series of transition metals including Fe(II), Co(II), Ni(II) and Zn(II). This system shows an efficient remote transfer of stereogenecity from the helicene core to the bipyridine-metal coordination sites and subsequently the entire cages. While the Fe(II), Co(II) and Ni(II)-derived M2L3 (M for metal and L for ligand) cages exhibit quasi-reversible redox features, the Zn(II) analogues reveal prominent yellow circularly polarized luminescence. Interestingly, with the addition of Na2SO4, the Zn2L3 cages reassemble into sextuple-stranded Zn6L6(SO4)4 cages in which three Zn2L2 units are bound together by four sulfates and further coalesced by offset inter-ligand π-π interactions.
Single-atom site catalysts (SACs) and two-dimensional materials (2DM) have gradually become two hot topics in catalysis over the past decades. Their combination with each other can further endow the derived SACs with extraordinary properties such as high loading, identical active sites, uniform coordination environment, distinctive metal-support interaction, and enhanced catalytic activities. In this review, we highlight the recent development in this specific research topic according to the types of substrates and focus on their applications in energy conversion field. Additionally, we also make a brief introduction to the synthesis and characterization methods for SACs supported on 2DM (SACs/2DM). Finally, the challenges and perspectives are summarized based on the current development status. It is believed that this work will make contributions to the rational design and fabrication of novel SACs/2DM, promoting their practical energy applications in the future.
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