Latest ArticlesIn recent years, the application of smartphone in various fields has received great attention, and it has become a promising tool in virus detection, data processing and data exchange. During the rapid spread of COVID-19 around the world, many traditional detection methods have been combined with smartphone to assist in the analysis and detection of the novel coronavirus (SARS-CoV-2), including electrochemistry, fluorescence and colorimetry. With the gradual development of artificial intelligence (AI), the combination of AI and smartphone to analyze SARS-CoV-2 was also the focus of research. Based on the summary of the traditional methods combined with smartphone to detect SARS-CoV-2 virus, in addition to AI-based data processing, AI algorithms are also employed for SARS-CoV-2 detection itself. This review discussed both strategies and focused on the application of the former. The combination of AI algorithm and smartphone to detect SARS-CoV-2 has high accuracy, which is more conducive to meeting the needs of portable detection. In addition, the classification of SARS-CoV-2 virus samples in biological fluids such as blood and saliva was also discussed. Finally, this paper briefly discussed the limitations of using smartphone analysis to detect SARS-CoV-2, as well as the prospect and future development of virus detection. In conclusion, the detection methods based on smartphone and AI algorithms show great potential in the detection of SARS-CoV-2 and can be a valuable complement to traditional analysis methods.
A nonsymmetrical PNN pincer ligand [6-(Bu2PNH)C5H4N-2-(3-Mes)C3H2N2] and its corresponding cobalt-N2 complex were synthesized and characterized. By the stoichiometric reaction of the PNN ligand lithium salt with CoCl2, the complex 3, (PNN)CoCl, was obtained. Then, reduction of 3 with NaBHEt3 under a dinitrogen atmosphere yielded complex 5, (PNN)Co(Ⅰ)(η1-N2). Single-crystal X-ray analysis, IR spectrum, and DFT calculations revealed that the dinitrogen in 5 was only weakly reduced by the cobalt center. The reactions of 5 with carbon monoxide and 2, 6-dimethylphenyl isocyanide gave carbonyl and isocyanide complexes 6 and 7 with the release of N2, respectively. Furthermore, these cobalt complexes, especially complex 5, demonstrated the capacity to convert dinitrogen to N(TMS)3 with moderate efficiency.
Herein, we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild conditions. Synergistic coordination of the monodentate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle intermediate. The protocol provides a variety of valuable α-aryl-substituted alkylamine products, and exhibited good functional group tolerance. The modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.
The stable coordinated metallo-complexes based on 2,2′:6′,2″-terpyridine (tpy) and its derivatives have been widely researched for various wide-ranging applications in photoelectronics, catalysis, sensor, photoluminescence, and so on. However, the most reported studies ignored the comprehensive comparison between structures modified by different positions and photoluminescence. Herein, we design a series of metallo-complexes which were assembled with tpy substituted triphenylamine (TPA) at different positions and metal ions and explored their photophysical properties. In the solution state, MLE2 based on the 5,5″-positions modification showed the highest PLQYs and PL intensity. With the increase of solvent polarity, MLB2 exhibit the largest redshift. In the solid state, from MLA2 to MLE2, the emission colours are gradually red-shifted from yellow to red. The findings in this work may pave a new way to design functional metallo-complexes, not just for PL properties.
The conjugate addition of in-situ generated (aza-)quinone methides (QMs) and indole imine methides (IIMs) emerged as a powerful protocol to access densely functionalized benzenes and indoles. Hydroxybenzyl alcohols, aminobenzhydryl alcohols, and varied indolylmethanols served as most effective precursors for the in-situ generation of such reactive species under acid conditions. The relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and -IIMs via the acid promoted dehydration process, thus enabling diverse challenging remote activation to proceed conjugate 1,6- and 1,8-additions. Moreover, the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs, thus inducing the remote nucleophilic dearomative additions. The conjugate additions of (aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chemistry in past decade. This review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.
Metal-organic frameworks (MOFs) combined with specific ligands are highly adaptable smart materials that can respond to external and physiological stimuli. In this study, we introduced a pyridinyl zwitterionic ligand with light/pH dual response into magnetic MOF composite (Fe3O4@ZW-MOF) for enrichment of phosphorylated peptides for the first time. The introduction of the developed ligand gives MOF material dual response properties. Light stimulation affects the generation/disappearance of free radicals of the pyridine derivative, resulting in a change in the charge gradient of the zwitterion, and zwitterion can also regulate the pH of the solution by adding acid or base. Therefore, the reversible capture and release of phosphorylated peptides can be easily achieved by adjusting light and pH. The established phosphorylated peptide enrichment platform exhibits high sensitivity (detection limit of 1 fmol), high selectivity (β-casein: BSA, 1:1000), and good reusability (7 cycles). In addition, the method was applied to the enrichment of phosphorylated peptides in complex systems (non-fat milk and human serum), demonstrating the feasibility of this method for phosphoproteom analysis. In conclusion, the synthesized Fe3O4@ZW-MOF is a promising MOF material, which provides the possibility to advance the application of responsive MOFs materials in proteomics.
Chemodynamic therapy (CDT) combined with dual phototherapy (photothermal therapy (PTT) and photodynamic therapy (PDT)) is an efficient way to synergistically improve anti-tumor efficacy. However, the combination of multiple modes often makes the composition of the system more complex, which is not conducive to clinical application. In this study, a dual phototherapy ligand carboxyl-modified Aza-BODIPY (BOD-COOH) and metal active center Cu2+ were used to construct multiple-modes metal-photosensitizer nanoparticles (BOD-Cu NPs) via one-step coordination self-assembly for combination therapy of CDT/PDT/PTT. In order to improve delivery efficiency, the targeted hydrophilic molecule pyridine-modified glucose derivative (G-Py) was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction. The Cu2+ in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione (GSH), and then catalyze Fenton-like reaction to generate hydroxyl radical (·OH) for CDT. In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDT-enhanced dual phototherapy.
Lithium-sulfur batteries (LSBs) boasting remarkable energy density have garnered significant attention within academic and industrial spheres. Nevertheless, the progression of LSBs remains constrained by the languid redox kinetics intrinsic to sulfur and the pronounced shuttle effect induced by lithium polysulfides (LiPSs), which seriously affecting the energy density, cycling life and rate capacity. The conceptualization and implementation of catalytic materials stand acknowledged as a propitious stratagem for orchestrating kinetic modulation, particularly in excavating the conversion of LiPSs and has evolved into a focal point for disposing. Among them, chalcogenide catalytic materials (CCMs) have shown satisfactory catalytic effects ascribe to the unique physicochemical properties, and have been extensively developed in recent years. Considering the lack of systematic summary regarding the development of CCMs and corresponding performance optimization strategies, herein, we initiate a comprehensive review regarding the recent progress of CCMs for effective collaborative immobilization and accelerated transformation kinetics of LiPSs. Following that, the modulation strategies to improve the catalytic activity of CCMs are summarized, including structural engineering (morphology engineering, surface/interface engineering, crystal engineering) and electronic engineering (doping and vacancy, etc.). Finally, the application prospect of CCMs in LSBs is clarified, and some enlightenment is provided for the reasonable design of CCMs serving practical LSBs.
Herein, we report the first visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO2 to synthesize hydroxy acid derivatives. A variety of valuable β-, γ-, δ-, ε-hydroxy acid derivatives are obtained in moderate to high yields under mild conditions. This protocol shows noteworthy functional-group compatibility, high chemo- and regioselectivities under transition-metal-free conditions with an inexpensive organo-dye as photosensitizer. Mechanistic studies indicate that the benzylic carbanion is generated as an intermediate via the sequential single electron transfer (SSET) process.
TiO2-based films are one of the most attractive photocatalysts owing to their highly cost-effective properties. Nevertheless, most TiO2-based photocatalytic films for dye degradation are in the form of robust films (without flexibility), TiO2 coatings on carbon matrix (with leakage risk), or surface-covered TiO2 hybrids (not favorite to contact with external molecules). Therefore, the development of durable and highly efficient TiO2 photocatalytic films for dye degradation is still needed. Here, we fabricated soft photocatalytic hybrid membranes (TANFs) from TiO2 nanotubes (TiNT) and aramid nanofiber (ANF) by a facile vacuum filtration process. The similar morphology and dimension of TiNT and ANF enable them intricately intertwine with each other in the membrane network. Under an appropriate mixing ratio, the TANF exhibited significantly improved optical and mechanical properties. When used for dye degradation, the membrane showed excellent photocatalytic performance and could keep stable activity and integrated state for repeated usage.
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