Discovery of pyrethalkalines A and B as potent analgesics with unprecedented chemical skeletons dual targeting TRPM8 and Kv1.2 ion channels
aState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
bThe Xinjiang Key Laboratory of Natural Medicine Active Components and Drug Release Technology, Pharmacy College of Xinjiang Medical University, Urumqi 830011, China
cHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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