Chinese Chemical Letters

Chinese Chemical Letters ›› 2026, Vol. 37 ›› Issue (3) : 111404 - . DOI: 10.1016/j.cclet.2025.111404

Communication

A hypoxia-activated copper ion nanoexchanger for cancer immunotherapy by in situ precise production of immunogenic cell death inducer

Xinlu Zhang ^a ,
Yongxin Liu ^a ,
Huan Li ^a ,
Shutong Chen ^a ,
Guocheng Wang ^a ,
Xu Zhang ^a ,
Chen Cao ^a ,
Xiaoyuan Chen ^b^,^c^,^d^,^e^,^f^,^g^,^h^,ⁱ ,
Sheng Wang ^a

Author information +

^aSchool of Life Sciences, Faculty of Medicine, Tianjin University, Tianjin 300072, China

^bDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore

^cDepartment of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore 117575, Singapore

^dDepartment of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117575, Singapore

^eDepartment of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore 117544, Singapore

^fClinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore

^gNanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

^hTheranostics Center of Excellence (TCE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 138667, Singapore

ⁱInstitute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore

E-mail addresses: chen.shawn@nus.edu.sg (X. Chen)

shengwang@tju.edu.cn (S. Wang)

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Received	Accepted	Published
2025-03-18	2025-06-03
Issue Date
2026-10-29

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