^aDepartment of Chemical Engineering, Tsinghua University, Beijing 100084, China

^bState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

^cKey Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China

^dInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China

^eSchool of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, Northern Ireland, United Kingdom

^fKey Lab for Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, China

^gCenter for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China