Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
b Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium
c Department of Applied Chemistry, Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China
d Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China
e Office of Academic Affairs, Yunnan University of Finance and Economics, Kunming 650221, China
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