Chinese Chemical Letters

Chinese Chemical Letters ›› 2022, Vol. 33 ›› Issue (8) : 4126 - 4132. DOI: 10.1016/j.cclet.2021.11.065

Communication

Programmable endonuclease combined with isothermal polymerase amplification to selectively enrich for rare mutant allele fractions

Junman Chen ^a^,^b^,^c^,¹ ,
Tian Qiu ^d^,¹ ,
Michael G. Mauk ^c ,
Zheng Su ^e ,
Yaguang Fan ^f ,
Dennis J. Yuan ^b ,
Qinghua Zhou ^g ,
Youlin Qiao ^e ,
Haim H. Bau ^c ,
Jianming Ying ^d^,^* ,
Jinzhao Song ^b^,^c^,^**

Author information +

^a Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China

^b The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China

^c Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, United States

^d Department of Pathology, National Cancer Center / National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

^e Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

^f Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China

^g Sichuan Lung Cancer Institute, Sichuan Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

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Received	Accepted	Published
2021-09-23	2021-11-23
Issue Date
2025-12-19

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