^a Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

^b Department of Orthopedics and Traumatology, Nanning Hospital of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China

^c Department of Orthopedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710000, China

^d Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai 200444, China

^e Institute of Translational Medicine, Shanghai University, Shanghai 200444, China

^f Organoid Research Center, Shanghai University, Shanghai 200444, China

^g National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China

^h Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of Fudan University, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China

ⁱ Wenzhou Institute of Shanghai University, Wenzhou 325000, China