Home Journals Articles Updates About
CN
image
收藏切换
Amine-catalyzed synthesis of N2-sulfonyl 1, 2, 3-triazole in water and the tunable N2-H 1, 2, 3-triazole synthesis in DMSO via metal-free enamine annulation
收藏切换
PDF
Yanhui Guo, Yunyun Liu, Jie-Ping Wan*
Chinese Chemical Letters | 2022, 33(2) : 855 - 858
Less
收藏切换
Chinese Chemical Letters | 2022, 33(2): 855-858
• Communication •
Amine-catalyzed synthesis of N2-sulfonyl 1, 2, 3-triazole in water and the tunable N2-H 1, 2, 3-triazole synthesis in DMSO via metal-free enamine annulation
Full
Yanhui Guo, Yunyun Liu, Jie-Ping Wan*
Affiliations
  • College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China
Published: 2022-02-15 doi: 10.1016/j.cclet.2021.08.003
Outline
收藏切换

The selective synthesis of N2-sulfonyl and N2-H 1, 2, 3-triazoles via organocatalytic annulation of enaminone/enaminoester with sulfonyl azide has been realized. The unconventional selectivity providing N2-sulfoyl 1, 2, 3-triazoles takes place in pure water, wherein the hydrogen bond effect between water and the intermediate resulting from enamine-azide corporation accounts for the novel reaction selectivity. On the other hand, the reactions conducted in DMSO specifically afford N2-H 1, 2, 3-triazoles in the absence of such hydrogen bond effect.

Enaminone  /  Annulation  /  N2-sulfonyl 1, 2, 3-triazole  /  Selectivity  /  Green synthesis  /  Sulfonyl azide
Yanhui Guo, Yunyun Liu, Jie-Ping Wan. Amine-catalyzed synthesis of N2-sulfonyl 1, 2, 3-triazole in water and the tunable N2-H 1, 2, 3-triazole synthesis in DMSO via metal-free enamine annulation[J]. Chinese Chemical Letters, 2022 , 33 (2) : 855 -858 . DOI: 10.1016/j.cclet.2021.08.003
Full Text
Less
Among the numerous known heterocyclic systems, the 1, 2, 3-triazole ring is inarguably one of the most useful and successful ones which has exhibited ubiquitous and distinctive applications in a variety of scientific and industrial areas, including but not limited in drug discovery, chemical biology, science of functional materials as well as diversity & target oriented organic synthesis [1-4]. Accordingly, tremendous efforts have been afforded to the development of synthetic methodology towards 1, 2, 3-triazoles [5-8]. Representatively, the click alkyne azide cycloaddition [9-15], organocatalytic 1, 2, 3-triazole annulation [16, 17], nonmetal reagent-catalyzed 1, 2, 3-triazole annulation [18-20] and even azide-free 1, 2, 3-triazole annulation [21-24] have contributed significantly to the great success of 1, 2, 3-triazole chemistry. On the contrary, owing to the internally higher molecular stability, most of the reported methods on 1, 2, 3-triazoles provide either N1-substituted or N1-H 1, 2, 3-triazole as products. Comparing with the N1-1, 2, 3-triazole synthesis, equivalent synthetic methods toward N2-H or N2-substituted 1, 2, 3-triazoles are much less available [25-31]. Many N2-substituted 1, 2, 3-triazoles, however, have been proved to be highly valuable for their individual role as central backbone in biologically functional molecules. For example (Fig. 1), the N2-substituted 1, 2, 3-triazoles A are reported with muscarinic agonist activity wherein the N2-substitutent is found to be crucial [32]. The N2-substituted 4-hydroxyl 1, 2, 3-trialzoles B are bioisosteres of glutamic acid which exhibit promise in new drug design with enhanced binding affinity [33]. The N2-acetyl triazole of betulin (C) is a compound possessing potent cytotoxic activity to different cancer cell lines and low toxicity to normal cells [34]. Moreover, suvorexant (D) is a potent, brain penetrant dual orexin receptor antagonist with potential application in the treatment of primary insomnia (Fig. 1) [35]. Considering the high application space of N2-substituted 1, 2, 3-triazoles, developing and designing practical method for the synthesis of such compounds is thus an issue of high urgency.
As easily accessible synthons with versatile versions of presence, enaminones and analogous enaminoesters have been identified with extraordinary broad application in the synthesis of numerous organic products in recent decade [36-44]. Specifically, employing these stable enamines as the donors of either C4-C5 or N3-C4-C5 fragment have successfully enabled the synthesis of 1, 2, 3-triazole with a broad array of structural features, including the 1, 5-disubstitued 1, 2, 3-triazoles [45, 46], 1, 4-disubstitued 1, 2, 3-triazoles [47, 48], free N1-H 1, 2, 3-triazoles [49, 50], and full substituted 1, 2, 3-triazoles [51-53]. However, such enamines have not previously been observed to be capable of participating the synthesis of N2-substituted or N2-H 1, 2, 3-triazoles [54]. During our recent efforts in developing novel and sustainable synthesis, we have disclosed that the NH- or NH2-functionalized enaminones/enaminoesters could be used for designing water-mediated green synthetic by making use of enamines' inherent hydrophilicity resulting from the hydrogen bond effect between enamines and water [55-58]. Herein, we report our work on the hydrophilic enamine-based reactions towards the synthesis of N2-subtituted 1, 2, 3-triazoles in water without using any metal reagent. In addition, using DMSO as medium has led to the selective synthesis of N2-H 1, 2, 3-triazoles via similar metal-free operation. Notably, this is the first example on the N2-sulfonyl 1, 2, 3-triazole synthesis via direct triazole annulation, and previous methods were based on the N-sulfonylation of prior prepared N-H-1, 2, 3-triazoles [59-61].
At the beginning, the reaction of enaminoester 1a and tosyl azide 2a were employed with t-BuONa, which gave rise to N2-tosyl 1, 2, 3-triazole 3a with 42% yield by heating at 40 ℃ in water medium (Table 1, entry 1). In a series of parallel entries employing different organic and inorganic base species, TMEDA exhibited among the best effect in promoting this reaction (entries 2–7). Notably, organic solvents such as MeCN, EtOH, toluene, and DCM all displayed poor applicability as medium for the reaction, disclosing the specific advantage of water in the present reaction (entries 8–11). Screening the reaction temperature indicated that enhancing the temperature to 60 ℃ was most favorable (entries 12–14). Later on, the loadings of 2a as well as TMEDA catalyst were varied, respectively. However, not evident improvement was observed (entries 15–17). Further increased yield of 3a was reached by prolonging the reaction time to 12 h (entry 18, Table 1).
With the satisfactory result given by the optimized reaction conditions, the scope of the reaction in synthesizing N2-substituted 1, 2, 3-triazoles were then investigated. Based on the results afforded by the experiments, the present method for the synthesis of N2-sulfonyl 1, 2, 3-triazoles was generally applicable to the reactions of NH2-functionalied enamines and sulfonyl azides. First, for the enamine substrate, the enamines featured with ester (3a-3d, 3l-3m and 3r, Scheme 1), aryl ketone (3e-3h, 3n-3q, 3s, 3v and 3y-3z, Scheme 1) as well as alkyl ketone fragment (3i-3k, 3t-3u and 3w-3x, Scheme 1) all displayed smooth tolerance to the expected synthesis. On the other hand, besides tosyl azide, the sulfonyl azides functionalized with alkoxylphenyl (3l and 3r-3u, Scheme 1), halophenyl (3n, 3o and 3x, Scheme 1), alkylphenyl (3p-3q, Scheme 1) and naphthyl (3m and 3v-3w, Scheme 1) were also practical reactants for the titled synthesis. The electron withdrawing group functionalized phenyl sulfonyl azides gave lower yield of the target products (3o and 3x, Scheme 1). Using methyl sulfonyl azide to react with 1a, however, did not afford the product. Performing the reaction for 3b synthesis in 4 mmol scale gave satisfactory yield. No such 1, 2, 3-triazole was observed in the reaction of phenyl azide with 1a, either. The structure of N2-substituted 1, 2, 3-triazoles was confirmed by the single crystal analysis on 3d (CCDC: 1868189).
To further investigate the effect of reaction medium to the reaction outcome, the reactions in DMSO, a non-proton organic solvent, were then conducted. Interestingly, the selective reaction pathway providing N2-H 1, 2, 3-triazole was observed. The brief examination on this reaction showed that different NH2-enamines and sulfonyl azides could be independently used for the synthesis of N2-H 1, 2, 3-triazoles 4 with generally good to excellent yields (Scheme 2).
In the process of exploring reaction mechanism, the isotope labeling experiment using 15N-labelled enaminone 1a was employed to react with 2a to the standard conditions. The isolation of 15N-labelled product 15N-3a confirmed that the C-N bond in enaminone substrate was not broken (Scheme 3a). Similar result was obtained from the reaction synthesizing product 15N-4a in DMSO (Scheme 3b), which further supported the above conclusion. Another experiment subjecting N-H-1, 2, 3-triazole 4a with TsNH2 did not provide product 3a under the water-based standard conditions (Scheme 3c), indicating that 4a was not formed during the generation of N2-sulfonyl triazole product.
According to the information given by control experiments and the selective formation of different products, a plausible reaction mechanism involving hydrogen bond is proposed. As outlined in Scheme 4, initially, the deprotonation of enaminone 1 takes place via its isomeric form 1′ in the presence of base, leading to the formation of anion intermediate 5. The incorporation of 5 with tosyl azide and the in situ generated BH provides intermediate 6 and regenerates the base. The tautomerization of 6 gave rise to intermediate 7. Because of the presence of unsymmetrical N=N=N structure in this intermediate, the cyclization based on the nucleophilic addition of the amino group to the N=N bond may take place via two different site selective pathways. For the reactions in water, the NH site might be masked by the hydrogen bond, which induces the addition of NH2 group to the N-site connected to the Ts group (path a) [21]. This selective cyclization gives intermediate 8 which eliminates NH3 (observed by GC-MS, see Supporting information) to provide products 3. On the other hand, when performing the reactions in non-protonic DMSO medium, without the effect of hydrogen bond in the =N–H site, the attack of the NH2 group takes place selectively to this less steric site (path b), which enables the formation of cyclic intermediate 9. The elimination of TsNH2 (observed by GC-MS, see Supporting information) from this intermediate then provides products 4.
In summary, by employing enaminones and sulfonyl azide as starting materials, we have established a new method for the synthesis of rarely accessed N2-sulfonyl 1, 2, 3-triazoles in pure water medium. In addition, the reactions have been identified with broad substrate scope and high efficiency using only low loading amine (5 mol% TMEDA) as catalyst without using any metal reagent. Notably, switching the reaction medium to DMSO leads to the selective synthesis of N2-H 1, 2, 3-triazoles with identical substrates. The unprecedented outcome for enaminone chemistry, the incomparable green reaction conditions as well as the selectivity tunable synthesis of N2-H 1, 2, 3-triazoles constituted the specific advantages of the present work.
Declaration of competing interest
Less
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgments
Less
This work is financially supported by the National Natural Science Foundation of China (No. 21861019) and Natural Science Foundation of Jiangxi Province (No. 20202ACBL203006).
Supplementary materials
Less
Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.cclet.2021.08.003
References
Less
[1]
K. Bozorov, J. Zhao, H.A. Aisa, Bioorg. Med. Chem.27 (2019) 3511-3531.
[2]
J. Totobenazara, A.J. Burke, Tetrahedron Lett. 56 (2015) 2853-2859.
[3]
H.M.L. Davies, J.S. Alford, Chem. Soc. Rev. 43 (2014) 5151-5162.
[4]
D.T.G. Gonzaga, D.R. da Rocha, F.C. da Silva, et al., Curr. Top. Med. Chem. 13 (2013) 2850-2865.
[5]
J.S.S. Neto, G. Zeni, Coord. Chem. Rev. 409 (2020) 213-217.
[6]
Z. Chen, Z. Liu, G. Cao, et al., Adv. Synth. Catal. 359 (2017) 202-224.
[7]
S. Noriega, E. Leyva, E. Moctezuma, et al., Curr. Org. Chem. 24 (2020) 536-549.
[8]
D. Alves, B. Goldani, E.J. Lenardão, et al., Chem. Rec. 18(2018) 527-542.
[9]
V.V. Rostovtsev, L.G. Green, V.V. Fokin, et al., Angew. Chem. Int. Ed. 41 (2002) 2596-2599.
[10]
C.W. Tornøe, C. Christensen, M. Meldal, J. Org. Chem. 67 (2002) 3057-3064.
[11]
E.J. Yoo, M. Ahlquist, S.H. Kim, et al., Angew. Chem. Int. Ed. 46 (2007) 1730-1733.
[12]
L. Zhang, X. Chen, P. Xue, et al., J. Am. Chem. Soc. 127 (2005) 15998-15999.
[13]
W. Song, N. Zheng, Org. Lett. 19 (2017) 6200-6203.
[14]
M. Li, N. Zheng, J. Li, et al., Green Chem. 22 (2020) 2394-2398.
[15]
X. Duan, N. Zheng, M. Li, et al., Chin. Chem. Lett. 32 (2021) DOI: 10.1016/j.cclet.2021.05.037.
[16]
S.S.V. Ramasastry, Angew. Chem. Int. Ed. 53 (2014) 14310-14312.
[17]
D.B. Ramachary, A.B. Shashank, S.S. Karthik, Angew. Chem. Int. Ed. 53 (2014) 10420-10424.
[18]
X. Zhang, K.P. Rakesh, H.L. Qin, Chem. Commun. 55 (2019) 2845-2848.
[19]
L. Deng, Y. Liu, J.P. Wan, Eur. J. Org. Chem. (2020) 5606-5609.
[20]
D. Zhang, Y. Fan, Z. Yan, et al., Green Chem. 21 (2019) 4211-4216.
[21]
J.P. Wan, D. Hu, Y. Liu, et al., ChemCatChem7(2015) 901-903.
[22]
Z. Chen, G. Cao, J. Song, et al., Chin. J. Chem. 35(2017) 1797-1807.
[23]
Z. Chen, Q. Yan, Z. Liu, et al., Angew. Chem. Int. Ed. 52 (2013) 13324-13328.
[24]
Z.J. Cai, X.M. Lu, Y. Zi, et al., Org. Lett. 16 (2014) 5108-5111.
[25]
H.N. Liu, H.Q. Cao, C.W. Chung, et al., Org. Lett. 22 (2020) 1396-1401.
[26]
P. Wu, Y. He, H. Wang, et al., Org. Lett. 22 (2020) 310-315.
[27]
P. Bao, H. Yue, N. Meng, et al., Org. Lett. 21 (2019) 7218-7222.
[28]
S. Roshandel, M.J. Lunn, G. Rasul, et al., Org. Lett. 21(2019) 6255-6258.
[29]
X. Deng, X. Lei, G. Nie, et al., J. Org. Chem. 82 (2017) 6163-6171.
[30]
S. Mamijo, T. Jin, Z. Huo, et al., J. Am. Chem. Soc. 125 (2003) 7786-7787.
[31]
Z. Li, Q. Wei, L. Song, et al., Org. Lett. 21 (2019) 6413-6417.
[32]
E.K. Moltzen, H. Pedersen, K.P. Bøgesø, et al., J. Med. Chem. 37 (1994) 4085-4099.
[33]
A.C. Pippione, F. Dosio, A. Ducime, et al., MedChemCommun6 (2015) 1285-1292.
[34]
V.V. Grishko, I.A. Tolmacheva, V.O. Nebogatikov, et al., Eur. J. Med. Chem. 127 (2017) 629-639.
[35]
C.D. Cox, M.J. Breslin, D.B. Whitman, et al., J. Med. Chem. 53 (2010) 5320-5332.
[36]
L. Gan, Y. Liu, J.P. Wan, et al., J. Org. Chem. 86 (2021) 1231-1237.
[37]
Q. Yu, Y. Zhang, J.P. Wan, Green Chem. 21 (2019) 3436-3441.
[38]
L. Fu, Z. Xu, J.P. Wan, et al., Org. Lett. 22 (2020) 9518-9523.
[39]
L. Fu, Y. Liu, J.P. Wan, Org. Lett. 23 (2021) 4363-4367.
[40]
D. Hu, L. Yang, J.P. Wan, Green Chem. 22 (2020) 6773-6777.
[41]
D. Ba, Y. Chen, W. Lv, et al., Org. Lett. 21 (2019) 8603-8606.
[42]
Y. Yuan, W. Hou, D. Zhang-Negrerie, et al., Org. Lett. 16 (2014) 5410-5413.
[43]
F. Gu., W. Yao, Chin. J. Org. Chem. 40 (2020) 4384-4386.
[44]
Q. Yu, Y. Liu, J.P. Wan, Chin. Chem. Lett. 32 (2021) DOI: 10.1016/j.cclet.2021.04.037.
[45]
G. Cheng, X. Zeng, J. Shen, et al., Angew. Chem. Int. Ed. 52 (2013) 13265-13268.
[46]
J.P. Wan, S. Cao, Y. Liu, J. Org. Chem. 80 (2015) 9028-9033.
[47]
J.P. Wan, S. Cao, Y. Liu, Org. Lett. 18 (2016) 6034-6037.
[48]
S. Cao, Y. Liu, J.P. Wan, et al., ChemCatChem10 (2018) 5007-5011.
[49]
J. Thomas, V. Goyvaerts, S. Liekens, et al., Chem. Eur. J. 22 (2016) 9966-9970.
[50]
L. Yang, Y. Wu, J.P. Wan, et al., Beilstein J. Org. Chem. 14 (2018) 2348-2353.
[51]
L. Deng, Y. Liu, J.P. Wan, et al., J. Org. Chem. 84 (2019) 14179-14186.
[52]
A. De Nino, V. Algieri, M.A. Tallarida, et al., Eur. J. Org. Chem. (2019) 5725-5731.
[53]
N. Guo, X. Lin, H. Xu, et al., Org. Biomol. Chem. 17 (2019) 6148-6152.
[54]
T. Opsomer, W. Dehaen, Chem. Commun. 57 (2021) 1568-1590.
[55]
Y. Guo, L. Wei, J.P. Wan, et al., J. Org. Chem. 84 (2019) 2984-2990.
[56]
X. Zheng, J.P. Wan, Adv. Synth. Catal. 361 (2019) 5690-5694.
[57]
L. Gan, L. Wei, J.P. Wan, ChemistrySelect5 (2020) 7822-7825.
[58]
I. Elghmry, Y. Al-Faiyz, Tetrahedron Lett. 57(2016) 110-112.
[59]
R.J. Reddy, A. Shankar, M. Waheed, et al., Tetrahedron Lett. 59 (2018) 2014-2017.
[60]
M. Yamauchi, T. Miura, M. Murakami, Heterocycles80 (2010) 177-181.
[61]
T. Beryozkina, I.V. Efinov, W.F. Fabian, et al., Tetrahedron71 (2015) 6189-6195.
Appendix
Less
Year 2022 volume 33 Issue 2
PDF
49
26
Cite this Article
BibTeX
Article Info
doi: 10.1016/j.cclet.2021.08.003
  • Receive Date：2021-05-30
  • Online Date：2025-12-12
  • Published：2022-02-15
Article Data
Affiliations
History
  • Received：2021-05-30
  • Revised：2021-07-30
  • Accepted：2021-08-02
Affiliations
    College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China
References
Share
https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.08.003
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House