Rapidly diastereoselective assembly of ten-membered <i>N</i>-heterocycles between two 1,3-dipoles and their diversity to access fused <i>N</i>-heterocycles

Rapidly diastereoselective assembly of ten-membered N-heterocycles between two 1,3-dipoles and their diversity to access fused N-heterocycles

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Yan Luo^a^,¹, Yan-Jiao Lu^a^,¹, Mei-Mei Pan^a^,¹, Yu-Feng Liang^a, Wei-Min Shi^c, Chun-Hua Chen^*^,^b, Cui Liang^a, Gui-Fa Su^*^,^a, Dong-Liang Mo^*^,^a

Chinese Chemical Letters | 2025, 36(5) : 110207

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Chinese Chemical Letters | 2025, 36(5): 110207

• Communication •

Rapidly diastereoselective assembly of ten-membered N-heterocycles between two 1,3-dipoles and their diversity to access fused N-heterocycles

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Yan Luo^a^,¹, Yan-Jiao Lu^a^,¹, Mei-Mei Pan^a^,¹, Yu-Feng Liang^a, Wei-Min Shi^c, Chun-Hua Chen^*^,^b, Cui Liang^a, Gui-Fa Su^*^,^a, Dong-Liang Mo^*^,^a

Affiliations

^a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China

^b Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commision, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China

^c School of Medicine, Guangxi University of Science and Technology, Liuzhou 545006, China

Published: 2025-05-15 doi: 10.1016/j.cclet.2024.110207

Outline

Abstract

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The development of general and practical strategies toward the construction of medium-sized rings is still challenging in organic synthesis, especially for the multiple stereocenters control of substituted groups on the ring owing to the long distance between groups. Thus, stereoselective synthesis of multi-substituted ten-membered rings is attractive. Herein, a rapid assembly of various highly substituted ten-membered nitrogen heterocycles between two 1,3-dipoles through a tandem [3 + 3] cycloaddition/aza-Claisen rearrangement of N-vinyl-α,β-unsaturated nitrones and aza-oxyallyl or oxyallyl cations are disclosed. Products containing two or multiple stereocenters could be obtained in up to 96% yield with high regioselectivity and diastereoselectivity. Selective N-O bond cleavages of ten-membered nitrogen heterocycles lead to various novel 5,6,6-perifused benzofurans, bicyclo[4.4.0] or bicyclo[5.3.0] skeletons containing three or multiple continuous stereocenters in good yields and high diastereoselectivity. Biological tests show that the obtained ten-membered N-heterocycles and bicyclo[4.4.0] skeletons inhibited nitric oxide generation in LPS-stimulated RAW264.7 cells and might serve as good anti-inflammatory agents.

Key words

1,3-Dipole / Ten-membered N-heterocycles / Aza-Claisen rearrangement / [3+3] Cycloaddition / Nitrone / Anti-inflammatory

Cite this Article

Yan Luo, Yan-Jiao Lu, Mei-Mei Pan, Yu-Feng Liang, Wei-Min Shi, Chun-Hua Chen, Cui Liang, Gui-Fa Su, Dong-Liang Mo. Rapidly diastereoselective assembly of ten-membered N-heterocycles between two 1,3-dipoles and their diversity to access fused N-heterocycles[J]. Chinese Chemical Letters, 2025 , 36 (5) : 110207 - . DOI: 10.1016/j.cclet.2024.110207

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Medium-sized ring compounds (8 to 12 atoms) are important structural units which are particularly prevalent in biologically active molecules and natural products [1-3]. The construction of medium-sized ring compounds is still difficult because of their unfavourable transannular interactions and entropic effects. Ten-membered rings, are also one of the most important medium-sized units occurring in many bioactive compounds and natural products, such as muramine, protopine, dysazecine, salvia miltiorrhiza, and picralphylline (Scheme 1A) [4-7]. Intramolecular cyclization strategies have been successfully used for the synthesis of ten-membered ring compounds, such as cyclizations [8-11], ring-closing metathesis [12-14], ring expansion [15,16], aza-Claisen rearrangement (ACR) [17-19], and related transformations [20-23], however, these methods usually required multi-step synthesis of complex starting materials and lack of scaffold diversity. Moreover, the efficiency was always low owing to the long distance between the two reaction sites at the terminus and the increasing size of the rings. Thus, the development of novel strategy to access ten-membered ring skeletons is greatly in demand.

Cycloaddition reactions, as one of the most powerful and versatile strategies in the synthesis of cyclic molecules, have been made great progress toward the construction of five to seven-membered ring skeletons with biological activities [24-31]. Some examples were reported to prepare medium-sized ring molecules by direct cycloadditions, however, only limited examples toward the synthesis of ten-membered ring compounds by cycloadditions were reported up to now because it involves higher-order cycloadditions (Scheme 1B) [32-36]. For examples, Shibata’s [5 + 5] cycloaddition of 3,3-difluorooxindoles with vinyl ethylene carbonates [37], Zhao group developed [6 + 4] cycloaddition of vinyl oxetanes with azadienes [38], Deng and co-workers developed Pd-catalyzed [6 + 4] cycloaddition of π-allyl all carbon 1,6-dipoles with azadienes [39], Lu and Lan group reported [8 + 2] cycloaddition of vinyl carbamates with photogenerated ketenes [40], and Ma group developed [9 + 1] of 1,5-bisallenes with organic halides [41]. These higher-order cycloadditions toward the preparation of various ten-membered heterocycles have been shown the cycloaddition between 1,3-dipoles and various electrophiles (oxindoles, azadienes, ketenes, or allenes), however, the kind of [7 + 3] higher-order cycloaddition to access ten-membered ring has not yet been reported. Nitrones are important 1,3-dipoles and have been extensively used as building blocks in organic synthesis [42-45], which have been successfully used to prepare eight- or nine-membered ring compounds [46-49]. On the other hand, aza-oxyallyl or oxyallyl cations are also important intermediates to access five to seven-membered rings by [3 + 2], [3 + 3], and [4 + 3] cycloadditions [50-54]. Based on the [3 + 3] cycloaddition of N-aryl or alkyl nitrones with aza-oxyallyl or oxyallyl cations to form six-membered ring [55,56]. We surmised that regioselective [3 + 3] cycloaddition of N-vinyl-α,β-unsaturated nitrones with another 1,3-dipoles would give six-membered skeletons containing a quaternary carbon center and a 1,5-dinene moiety. To release the tension of quaternary carbon center [57,58], a sequence of aza-Claisen rearrangement (ACR) might offer a general and useful approach to access various ten-membered N-heterocycles containing two or multiple stereocenters, which perhaps could serve as important intermediates to access various fused N-heterocycles by N-O bond cleavage, such as 5,6,6-perifused benzofurans, bicyclo[4.4.0] or bicyclo[5.3.0] skeletons containing three or multiple continuous stereocenters (Scheme 1C). The N-vinyl-α,β-unsaturated nitrones were easily obtained by Chan-Lam reaction of oximes with alkenyl boronic acids under mild reaction conditions [59], and they would serve as 7-atom synthon in the higher-order [7 + 3] cycloaddition. As far as we known, the multiple stereocenters control in medium-sized ring is still a challenge because the substituted groups might be far away from each other to be controlled. While the stereo-defined ACR reaction would facilitate to control the stereocenters in ten-membered rings with high diastereoselectivity. This new method establishes the assembly of two types of 1,3-dipoles as a toolbox for the accessing ten-membered N-heterocycles containing two or more stereocenters.

Herein, we report an assembly of two 1,3-dipoles for the preparation of ten-membered ring compounds as well as their perifused N-heterocycles. The protocol includes the following points. (1) The ten-membered ring is constructed by copper-catalyzed [3 + 3] cycloaddition/aza-Claisen rearrangement under mild reaction conditions, which is interesting due to its value in addressing the formation of a ten-membered ring via [3 + 3] cycloaddition from N-vinyl-α,β-unsaturated nitrones with other 1,3-dipoles. (2) The structurally unique multi-substituted ten-membered rings might be used as a platform model for discovering some synthetically useful nitrogen perifused cycles. (3) This study might offer useful information for the designing ten-membered rings or N-perifused ring analogs with potent good bioactivity.

Our investigations started with N-vinyl-α,β-unsaturated nitrone 1a and aza-oxyallyl cation as a 1,3-dipole generated from α-bromoamide 2a as the model substrates. As shown in Table 1, 1a reacted with 2a affording the desired ten-membered ring product 3aa in 12% yield as single isomer in the presence of K₂CO₃ in 2,2,2-trifluoroethanol (TFE) (Table 1, entry 1). The structure of 3aa was determined by its X-ray diffraction analysis. The structure showed that C=N and C=C bonds in the ten membered ring are both E-configuration, and Ph and Me groups on the ring had a trans-relationship. Solvents screening revealed that MeCN gave 3aa in better yield than other solvents, such as toluene, THF, and DMSO (Table 1, entries 2-5). The test of Lewis acid catalysts showed that the addition of Lewis acid definitely promoted the reaction and CuOTf gave 3aa in the best result with 75% yield (Table 1, entries 6-11). The effect of bases indicated that the reaction ran smoothly either inorganic or organic base, especially for NEt₃ gave lower yield of 3aa (Table 1, entries 12-15, more details for optimization conditions, see Table S1 in Supporting information). Therefore, the optimal conditions for preparing 3aa was 20 mol% of CuOTf and K₂CO₃ as base in MeCN at room temperature.

With the optimized conditions in hand, the scope of N-vinyl-α,β-unsaturated nitrones 1 reacting with 2a was explored. As shown in Scheme 2, various dibenzylideneacetone-derived N-vinyl nitrones with electron-donating and electron-withdrawing groups at the para, meta, and ortho-positions of aryl rings proceeded smoothly to afford the corresponding ten-membered lactam products 3aa-3ga bearing two stereocenters in good yields only with trans-diastereomers. The chalcone-derived N-vinyl nitrones were also evaluated. The corresponding products 3ha-3na were obtained in good to excellent yields with trans-diastereomers only when either aryl ring was present with electron-donating or electron-withdrawing groups at para, or ortho-positions. The reaction also tolerated 2-thienyl group furnishing product 3na in 65% yield. While cinnamaldehyde-derived nitrone 1o delivered the desired product 3oa in 38% yield owing to the easy decomposition of nitrone 1o. In addition to α,β-unsaturated ketone moieties, the vinyl moieties on the N-atom of nitrones were also tested. The N-vinyl moieties could be present with linear and cyclic vinyl substituents, affording the corresponding ten-membered lactams in moderate to good yields (3pa-3ya). The monosubstituted or disubstituted linear vinyl groups could be present with alkyl and aryl groups bearing sensitive functional groups (3pa-3ta). The reaction also tolerated five to seven-membered carbon rings and pyran ring on the N-atom (3ua-3ya). Pleasingly, the R⁴ chains of nitrones with a chloro (1s), an ester (1t), and an acetal group (1y) on the six-membered ring also delivered 3sa, 3ta, and 3ya in 30%, 31%, and 45% yields. These sensitive functional groups could be easily converted to useful groups and it provides a synthetic handle for further manipulation.

Next, the substrate scope of α-bromohydroxymates 2 was evaluated (Scheme 3). It was found that a wide range of α-bromohydroxymates 2 reacting with N-vinyl nitrone 1a were smoothly converted to ten-membered lactams 3ab-3al in good yields. The R⁵ group could be present with different benzyloxy and alkyloxy groups. Pleasingly, the R⁵ group was compatible with vinyl and alkynyl groups (3ah-3ak). When the R⁶ group was methyl, ethyl or phenyl substituents and the R⁷ group was hydrogen, N-benzyloxy α-bromoamides (2j, 2k, and 2l) produced 3aj, 3ak, and 3al in 51%, 61%, and 66% yields, respectively, and their diastereomeric ratios were ranging from 7:1 to 10:1. These structures containing three stereocenters were determined by X-ray diffraction of compound 3ak, showing that the phenyl group and ethyl group was cis-position. This method provides a good approach to access ten-membered lactams bearing two or three substituents faraway from each other with high diastereoselectivity in the ten-membered rings. However, N-benzyl/N-phenyl α-bromoamides did not deliver the desired ten-membered ring products under the optimal conditions and only nitrone was recovered. The plausible reason is that the N-benzyl/N-phenyl substituent is not sufficient enough to stabilize the in situ-generated aza-oxyallyl cation [60,61].

Interestingly, as shown in Scheme 4, when α-bromo aryloxyamides 2 was used under the optimal conditions, the corresponding ten-membered lactams 3 could not be obtained. After further optimization conditions (Table S2 in Supporting information), we found that various α-bromo aryloxyamides 2 were reacted smoothly with different types of N-vinyl nitrones to afford the corresponding 5,6,6-perifused benzofuran heterocycles 4 containing five or six continuous stereocenters in acceptable yields as single diastereomers (4am-4ap). The structure of compound 4 was determined by X-ray diffraction analysis of compound 4am. From the structure of 4am we can see that 4 might be generated by a sequential [3,3]-sigmatropic rearrangement by the corresponding ten-membered lactams 3. Particularly, the N-vinyl moieties of nitrone 1v bearing cyclohexenyl and 1t bearing a linear chain with an ester group affording 4vm and 4tm in 50% and 42% yields, respectively. α-Bromo aryloxyamides 2n and 2o presented with methyl and fluoro groups delivered compounds 4an and 4ao in 66% and 65% yields, respectively. Compound 4ap containing six stereocenters was also obtained in 58% yield with one single isomer when the R⁶ and R⁷ groups of 2p were methyl and hydrogen. This method provides a facile one-pot approach to access perifused benzofuran heterocycles containing continuous stereocenters that are still challenging to be prepared.

The oxyallyl cation as 1,3-dipole generated from α-tosyloxy ketones 5 were also tested for this cascade reaction. As shown in Scheme 5, it was found that N-vinyl nitrone 1a reacted with α-tosyloxy ketone 5a with 3.0 equiv. of NEt₃ in TFE at 40 ℃ to afford the desired ten-membered heterocycle 6aa containing four stereocenters in 82% yield as single diastereomer (see Table S3 for optimizations in Supporting information). The relative configuration of the substituted groups in 6aa were determined by its NOESY spectra. Thus, various N-vinyl nitrones 1 and α-tosyloxy ketones 5 were evaluated. Chalcone-derived N-vinyl nitrone or N-vinyl moieties with linear or cyclic vinyl groups all tolerated the reaction conditions affording 6ha, 6ua-6wa, and 6ya in good yields. Interestingly, when α-tosyloxy ketones were varied from R⁵, R⁶, and R⁷ groups, products 6vb and 6vc were obtained in 76% and 49% yields, respectively. Moreover, α-tosyloxy ketone 5c was replaced by α-bromo ketone also afforded product 6vc in 34% yield with all carbon center in the ten-membered ring.

With the ten-membered lactams 3 in hand, we are interested in their properties under the thermal conditions (see Table S4 for optimizations in Supporting information). When compound 3aa was heated in MeCN at 80 ℃ for 12 h, a bicyclo[4.4.0] skeleton product 7aa containing three continuous stereocenters was obtained in 89% yield as single isomer, which was confirmed by X-ray diffraction analysis (CCDC 2050717). As shown in Scheme 6, The reaction tolerated ten-membered lactams 3va and 3ah, and delivered 7va and 7ah in 49% and 84% yields in high diastereoselectivity, respectively. The relative configuration of 7ah bearing four stereocenters was determined by X-ray diffraction analysis (CCDC 2050718). To our surprise, lactam 3ha with a phenyl at the R¹ group did not afford the desired piperidine 7ha at 80 ℃, however, a novel ten-membered lactam 8ha was obtained in 97% yield. The structure of 8ha was determined by X-ray diffraction analysis, showing an outside N-O bond cleavage. It was pleased to find that when lactams 3ha and 3ka were carried out at 120 ℃, the desired bicyclo[4.4.0] products 7ha and 7ka were obtained in 50% and 70% yields, respectively. These results indicated that the R¹ group in the ten-membered ring had a great effect on the formation of compounds 7 and 8 at the thermal conditions.

To better understand the thermal conversion of ten-membered lactams 3, control experiments were performed (Scheme 7). It was found that addition of radical trapping reagents TEMPO to compound 3aa at the thermal conditions inhibited the formation of 7aa with the recovery of 3aa only (Scheme 7a). Heating 8ha at 120 ℃ for 12 h did not afford 7ha, however, adding radical initiator BPO to 8ha delivered 7ha in 83% yield (Scheme 7b). Interestingly, when nitrone 1a reacted with 2a in the presence of Pd(dba)₂ and P,N-ligand L in HFIP at room temperature, 3aa was obtained in 36% yield accompanied by cycloadduct 3’ in 38% yield, which indicated that the first step of 1a reacting with 2a was [3 + 3] cycloaddition process.

To study the role of copper(Ⅰ), high resolution mass spectrum (HRMS) trace experiments were carried out (see Scheme S3 in Supporting information). It was found that the copper(Ⅰ) catalyst played as Lewis acid to promote the [3 + 3] cycloaddition and aza-Claisen rearrangement to form ten-membered ring. Based on the experimental studies, the mechanism for the formation of compounds 3, 4, 7, and 8 from N-vinyl nitrones 1 and α-bromohydroxamates 2 was proposed in Scheme 8. The active aza-oxyallylic cations generated from α-bromohydroxamates 2 in the presence of base coordinate with CuOTf to form copper(Ⅰ) intermediate A. Then, A undergoes [3 + 3] cycloaddition with N-vinyl nitrones 1 to give intermediate B. Intermediate B occurs stereo-defined [3,3]-rearrangement through chair transition state to give ten-membered lactams 3 with high diastereoselectivity and release Cu(Ⅰ) to finish the catalytic cycle. When the R⁵ was an aryl group, a further [3,3]-rearrangement of 3 gave compound 4. When the R⁵ was not an aryl group under the thermal conditions, homolytic cleavage of the outside N-O bond to form diradical intermediate C and R⁵O^•. Then, intermediate C underwent isomerization to give compound 8. Alternatively, C underwent radical addition to the C=N bond to result in compound 7 via intermediate D.

To show the utility of this cascade reaction to access ten-membered lactams, gram scale preparation of 3aa was carried out. As shown in Scheme 9, 1.0 g of N-vinyl nitrone 1a reacting with 2a delivered ten-membered lactam 3aa in 62% yield (1.01 g). Interestingly, the treatment of 3aa with Fe/NH₄Cl reductive conditions afforded 9 in 91% yield by N-O bond reductive cleavage. When 3aa reacted with Mo(CO)₆ in a mixture of MeCN/water open to air, compound 10 bearing a ketone with three stereocenters was obtained in 69% yield as single isomer. Treating 3aa with Zn dust and HOAc resulted in bicyclo[5.3.0] scaffold 11 in 62% yield with 3:1 diastereomers, while bicyclo[4.4.0] scaffold 12 was obtained in 51% yield by treating with NaBH₃CN, Zn dust, and HOAc. The structures of 9, 10, 11, and 12 were all determined by X-ray diffraction analysis (CCDC: 2050720-2050723). These versatile and fantastic conversions of ten-membered lactams provide a good approach to access these fused N-heterocycles containing multiple stereocenters that are difficult to prepare by other possible methods.

Finally, some prepared N-heterocycles were tested for anti-inflammatory activity by using RAW264.7 cells. As shown in Fig. 1a, most of the viability of cells treated with various N-heterocycles alone were similar or better than commercial anti-inflammatory drug indometacin. The LPS (1 µg/mL) stimulation for 24 h could markedly improve NO production, and compound 3ba and 7aa showed better NO inhibitory activity compared to indometacin at the concentration of 25 µmol/L (Fig. 1b). These preliminary results demonstrated that the designed ten-membered lactams or 5,6,6-perifused benzofurans and bicyclo[4.4.0] skeletons could prevent inflammatory response in RAW264.7 cells LPS-induced and might serve as good potent anti-inflammatory agents.

In summary, we have identified a modular synthesis of a range of valuable ten-membered N-heterocycles containing two or more continuous stereocenters in high diastereoselectivity through a formal [7 + 3] higher order cycloaddition reaction from N-vinyl-α,β-unsaturated nitrones and α-bromohydroxymates or α-tosyloxy ketones. Initial studies have shown that the obtained ten-membered N-heterocycles can be used as useful precursors for rapidly access highly functionalized benzofurans, bicyclo[4.4.0], and bicyclo[5.3.0] skeleton N-heterocyclic structures that are difficult to be prepared by traditional methods. The reaction shows a broad substrate scope and tolerated various sensitive functional groups. This mild and simple transformation provides a general approach to ten-membered rings and its fused N-heterocyclic derivatives. In addition, biological tests reveal that some of these designed ten-membered lactams and their derivatives including perifused benzofurans, bicyclo[4.4.0], and bicyclo[5.3.0] skeletons displayed their bioactivity as potent anti-inflammatory agents. We anticipate that this novel assembly higher-order [7 + 3] cycloaddition may provoke new developments in the formation of related medium-sized rings and the present protocol will find broad applications in synthetic and pharmaceutical chemistry.

Declaration of competing interest

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT authorship contribution statement

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Yan Luo: Writing – original draft, Methodology, Investigation. Yan-Jiao Lu: Methodology, Formal analysis, Data curation. Mei-Mei Pan: Methodology, Investigation, Data curation. Yu-Feng Liang: Investigation, Data curation. Wei-Min Shi: Resources, Data curation. Chun-Hua Chen: Supervision, Methodology, Investigation, Conceptualization. Cui Liang: Supervision, Resources, Data curation. Gui-Fa Su: Writing – review & editing, Supervision, Methodology, Conceptualization. Dong-Liang Mo: Writing – review & editing, Supervision, Project administration, Methodology, Funding acquisition, Formal analysis, Conceptualization.

Acknowledgments

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Financial support from the National Natural Science Foundation of China (No. 22071035), the Natural Science Foundation of Guangxi (Nos. 2023GXNSFDA026025, 2022GXNSFBA035494), Guangxi Minzu University Scientific Research Funds for Talent Introduction (2022KJQD14), and the Student Innovation Training Program (No. 202310602014), are greatly appreciated.

Supplementary materials

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Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.cclet.2024.110207.

References

Less

G.A. Molander, Acc. Chem. Res. 31 (1998) 603-609.

L. Yet, Chem. Rev. 100 (2000) 2963–3008.

R.L. Reyes, T. Iwai, M. Sawamura, Chem. Rev. 121 (2021) 8926–8947.

J.S. Choi, H.S. Kang, H.A. Jung, et al., Fitoterapia 72 (2001) 30–34.

S. Zergiebel, C. Fleck, H.D. Arndt, et al., Drug Res. 67 (2017) 466–475.

Y. Wada, H. Kaga, S. Uchiito, et al., J. Org. Chem. 72 (2007) 7301–7306.

B.E. Fink, P.R. Kym, J.A. Katzenellenbogen, J. Am. Chem. Soc. 120 (1988) 4334–4344.

J. Saadi, D. Lentz, H.U. Reissig, Org. Lett. 11 (2009) 3334-3337.

A. Kaga, H. Hayashi, H. Hakamata, et al., Angew. Chem. Int. Ed. 56 (2017) 11807-11811.

Y.W. Sun, X.Y. Tang, M. Shi, Chem. Commun. 51 (2015) 13937-13940.

Z. Wang, X. Wang, Q. Li, et al., Chin. Chem. Lett. 35 (2024) 109058.

A. Deiters, S.F. Martin, Chem. Rev. 104 (2004) 2199-2238.

N. Hegmann, L. Prusko, N. Diesendorf, et al., Org. Lett. 20 (2018) 7825-7829.

M. Lejkowski, H.J. Gais, P. Banerjee, et al., J. Am. Chem. Soc. 128 (2006) 15378-15379.

A.K. Clarke, W.P. Unsworth, Chem. Sci. 11 (2020) 2876-2881.

A. Lawer, J.A. Rossi-Ashton, T.C. Stephens, et al., Angew. Chem. Int. Ed. 58 (2019) 13942-13947.

B. Zhou, L. Li, X.-Q. Zhu, et al., Angew. Chem. Int. Ed. 56 (2017) 4015-4019.

B. Zhou, Y.Q. Zhang, K. Zhang, et al., Nat. Commun. 10 (2019) 3234.

X. Gao, M. Xia, C. Yuan, et al., ACS Catal. 9 (2019) 1645-1654.

R. Costil, Q. Lefebvre, J. Clayden. Angew. Chem. Int. Ed. 56 (2017) 14602-14606.

L. Huang, L.X. Dai, S.L. You, J. Am. Chem. Soc. 138 (2016) 5793-5796.

S. Liu, P. Ma, L. Zhang, et al., Chem. Sci. 14 (2023) 5220-5225.

L. Li, Z.L. Li, F.L. Wang, et al., Nat. Commun. 7 (2016) 13852.

L.Q. Chen, C.F. Zhu, S. Zhang, et al., Chin. Chem. Lett. 34 (2023) 108398.

X.H. Liu, H.F. Zheng, Y. Xia, et al., Acc. Chem. Res. 50 (2017) 2621-2631.

J. Polin, G.M. Grise-Bard, L. Barriault, Chem. Soc. Rev. 38 (2009) 3092-3101.

B.M. Trost, Z.X. Huang, C.M. Murhade, Science 362 (2018) 564-568.

R. Ushimaru, I. Abe, Nat. Chem. 15 (2023) 1056-1057.

Z. Zhou, Z.X. Wang, Y.C. Zhou, et al., Nat. Chem. 9 (2017) 590-594.

J. Du, Y.F. Li, C.H. Ding, Chin. Chem. Lett. 34 (2023) 108401.

J. Wang, Z. Li, S. Bai, et al., Chin. Chem. Lett. 34 (2023) 107823.

D. McLeod, M.K. Thøgersen, N.I. Jessen, et al., Acc. Chem. Res. 52 (2019) 3488-3501.

N. I. Jessen, D. McLeod, K.A. Jorgensen, Chem. 8 (2022) 20-30.

B. Zhang, K.B. Wang, W. Wang, et al., Nature 568 (2019) 122-126.

J.Z. Li, Y.H. Mo, L.Q. Yan, et al., CCS Chem. 4 (2022) 650-659.

J. Wang, L. Zhao, C. Zhu, et al., Chin. Chem. Lett. 33 (2022) 4549-4558.

H. Uno, K. Kawai, M. Shiro, et al., ACS Catal. 10 (2020) 14117-14126.

Y.N. Wang, L.C. Yang, Z.Q. Rong, et al., Angew. Chem. Int. Ed. 57 (2018) 1596-1600.

J.T. Chen, N. Lin, L. Xu, et al., Org. Chem. Front. 11 (2024) 1299-1304.

Q.L. Zhang, Q. Xiong, M.M. Li, et al., Angew. Chem. Int. Ed. 59 (2020) 14096-14100.

J. Cheng, X. Jiang, S. Ma, Org. Lett. 13 (2011) 5200-5203.

S.I. Murahashi, Y. Imada, Chem. Rev. 119 (2019) 4684-4716.

W.M. Shi, X.P. Ma, G.F. Su, et al., Org. Chem. Front. 3 (2016) 116–130.

K. Rück–Braun, T.H.E. Freysoldt, F. Wierschem, Chem. Soc. Rev. 34 (2005) 507–516.

M.F. Li, S.Q. Shi, T. Xu, et al., Chin. Chem. Lett. 34 (2023) 107751.

F. Rabasa–Alcañiz, A. Asensio, M. Sánchez–Roselló, et al., J. Org. Chem. 82 (2017) 2505–2514.

Y.Z. Wang, A. Hennig, T. Küttler, et al., Org. Lett. 22 (2020) 3145–3148.

N. Zou, J.W. Jiao, Y. Feng, et al., Org. Lett. 21 (2019) 481–485.

X.P. Ma, C.M. Nong, Y.F. Liang, et al., Green Chem. 22 (2020) 3827–3834.

A. Acharya, D. Anumandla, C.S. Jeffrey, J. Am. Chem. Soc. 137 (2015) 14858–14860.

A.E. Bouakher, A. Martel, S. Comesse, Org. Biomol. Chem. 17 (2019) 8467–8485.

C.S. Jeffrey, K.L. Barnes, J.A. Eickhoff, et al., J. Am. Chem. Soc. 133 (2011) 7688–7691.

B.M. Trost, Z. Huang, G.M. Murhade, Science 362 (2018) 564–568.

Z. Protich, L.L. Lowder, R.P. Hughes, et al., Chem. Sci. 14 (2023) 5196–5203.

M. Cordier, A. Archambeau, Org. Lett. 20 (2018) 2265–2268.

L. Hu, M. Rombola, V.H. Rawal, Org. Lett. 20 (2018) 5384–5388.

K.W. Quasdorf, L.E. Overman, Nature 516 (2014) 181–191.

Y. Liu, S.J. Han, W.B. Liu, et al., Acc. Chem. Res. 48 (2015) 740–751.

D. Kontokosta, D.S. Muller, D.L. Mo, et al., Beilstein J. Org. Chem. 11 (2015) 2097–2104.

Y. Kikugawa, Heterocycles 78 (2009) 571-607.

Y. Kikugawa, M. Shimada, M. Kato, et al., Chem. Pharm. Bull. 41 (1993) 2192-2194.

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Year 2025 volume 36 Issue 5

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doi: 10.1016/j.cclet.2024.110207

Receive Date：2024-04-16
Online Date：2025-10-29
Published：2025-05-15

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Received：2024-04-16
Revised：2024-06-26
Accepted：2024-07-02

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^c School of Medicine, Guangxi University of Science and Technology, Liuzhou 545006, China

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^*E-mail addresses: ChenChunHua@gxmzu.edu.cn (C.-H. Chen), gfysglgx@163.com (G.-F. Su), moeastlight@mailbox.gxnu.edu.cn (D.-L. Mo).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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Scheme 1 Cycloaddition strategies toward the preparation of ten-membered N-heterocycles.

Scheme 2 Substrate scope for N-vinyl nitrones 1. Reaction conditions: 1 (0.2 mmol), 2a (0.4 mmol, 2.0 equiv.), CuOTf (20 mol%), K₂CO₃ (0.4 mmol, 2.0 equiv.), MeCN (2.0 mL), r.t., 5-12 h, isolated yield.

Scheme 3 Substrate scope for α-bromohydroxymates 2. Reaction conditions: 1 (0.2 mmol), 2b-2l (0.4 mmol, 2.0 equiv.), CuOTf (20 mol%), K₂CO₃ (0.4 mmol, 2.0 equiv.), MeCN (2.0 mL), r.t., 5−24 h; isolated yield; dr = diastereomeric ratio.

Scheme 4 Substrate scope for α-bromo aryloxyamides 2. Reaction conditions: 1 (0.2 mmol), 2m-2p (0.4 mmol, 2.0 equiv.), CuOTf (20 mol%), K₂CO₃ (0.4 mmol, 2.0 equiv.), MeCN (2.0 mL), 80 ℃, 24 h; isolated yield. dr = diastereomeric ratio.

Scheme 5 Substrate scope for α-tosyloxy ketones 5. Reaction conditions: 1 (0.2 mmol), 5 (0.4 mmol, 2.0 equiv.), NEt₃ (0.4 mmol, 2.0 equiv.), TFE (2.0 mL), 40 ℃, 24 h, isolated yield.

Scheme 6 Thermal conversions of ten-membered lactams 3 to bicyclo[4.4.0] skeletons 7.

Scheme 7 Control experiments.

Scheme 8 Proposed mechanism.

Scheme 9 Gram scale preparation of 3aa and its diverse transformations.

Fig. 1 Biological studies. (a) The effect on the cell viability. (b) The effect on LPS-induced NO production.

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