Cancer Biology & Medicine

Cancer Biology & Medicine ›› 2025, Vol. 22 ›› Issue (7) : 832 - 853. DOI: 10.20892/j.issn.2095-3941.2025.0040

Original Article

GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

Tianyi Zhu ¹ ,
Qianwen Yang ¹ ,
Xiaozhe Qian ² ,
Xiuqi Wu ¹ ,
Jianchen Fang ³ ,
Yuli Lin ⁴^,⁵ ,
Yukuan Feng ⁶ ,
Jian Gao ⁷ ,
Qing Xia ¹

Author information +

¹Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

²Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

³Department of Pathology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

⁴Center for Medical Research and Innovation, Shanghai Pudong Hospital, Shanghai 200030, China

⁵Department of Immunology, Basic Medical School, Shanghai Medical College, Fudan University, Shanghai 200030, China

⁶Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China

⁷State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China

Correspondence to: Yuli Lin, Yukuan Feng, Jian Gao and Qing Xia, E-mail: yulilin@fudan.edu.cn, fengyukuan@tjmuch.com, lumenhj1937@163.com and xiaqing@shsmu.edu.cn

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Received	Accepted	Published
2025-02-06	2025-06-03
Issue Date
2026-11-07

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