Expert consensus on the detection and clinical application of tumor mutational burden
1Cancer Center, Department of Pathology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China
2Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
3Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Cancer Center, Westlake University School of Medicine, Hangzhou 310006, China
4Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China
5Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
6Ningbo Clinical Pathology Diagnosis Center, Ningbo 315100, China
7Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
8Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
9Department of Pathology, The Second Hospital of Jilin University, Changchun 130041, China
10Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
11Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
12Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
13Laboratory Medicine Center, Zhejiang Center for Clinical Laboratory, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou 310014, China
14Department of Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
15Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China
16Department of Pathology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
17Department of Pathology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China
18Department of Pathology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing 210004, China
19Department of Surgical Pathology Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, of China
20Department of Pathology, Shanghai Pudong Hospital, School of Medicine, Fudan University, Shanghai 201399, China
21Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
22Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
23Department of Pathology, Children’s Hospital Zhejiang University School of Medicine, Hangzhou 310005, China
24Department of Pathology, Stomatology Hospital, School of Stomatology, Zhejiang University, Hangzhou 310000, China
25Department of Pathology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China
26Department of Pathology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China
27Department of Pathology, The People’s Hospital of Leshan, Leshan 614000, China
28Department of Pathology, Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine, Hangzhou 310006, China
29Department of Pathology, Chun’an First People’s Hospital, Hangzhou 311700, China
30Department of Pathology, The Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou 215006, China
31Department of Pathology, The First People’s Hospital of Hangzhou Lin’an District, Affiliated Lin’an People’s Hospital, Hangzhou Medical College, Hangzhou 311300, China
32Department of Pathology, Tiantai County People’s Hospital, Taizhou 317200, China
33Department of Pathology, First People’s Hospital of Aksu, Aksu 843000, China
34Department of Pathology, Xianju People’s Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People’s Hospital, Affiliated Xianju’s Hospital, Hangzhou Medical College, Taizhou 317300, China
35Department of Pathology, Dinghai Branch of Zhejiang Provincial People’s Hospital, Zhoushan 316000, China
36Department of Pathology, Shulan (Hangzhou) Hospital, Hangzhou 310022, China
37Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
38Department of Pathology, Zhejiang Provincial People’s Hospital (Fuyang Campus), Hangzhou 311400, China
39Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Sarcoma, Peking University Cancer Hospital & Institute, Beijing 100142, China
40Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
41Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
42Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou 510080, China
43State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
44Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
45Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
46Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China
47Department of Thoracic Cancer, Jilin Cancer Hospital, Changchun 130012, China
48Department of VIP Inpatient, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
49Department of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
50Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310009, China
51Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
52Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
53Department of Respiratory Medicine, Clinical Medical School of Yangzhou University, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
54Department of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou 350014, China
55Department of Oncology, Guizhou Provincial People’s Hospital, Guiyang 550001, China
56Department of Internal Medicine, Cancer Center of PLA, Qinhuai Medical Area, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
57Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
58The Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China
59Department of Orthopedic Oncology Surgery, Beijing Ji shui tan Hospital, Peking University, Beijing 100035, China
60Department of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
61Department of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, Taizhou 317000, China
62Department of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou 350025, China
63Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
64Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100700, China
65Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China
66State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510300, China
67Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, China
68Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200123, China
69Department of Oncology, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China
70Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
71Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
72Department of Medical Oncology, The First Affiliated Hospital of Medicine, Xiamen University, Xiamen 361003, China
73Department of Medical Oncology, Cancer Hospital of China Medical University, Shenyang 110042, China
74Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu 610041, China
75Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
76Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China
77State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
78Department of Oncology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210029, China
79Department of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
80Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun 130033, China
81Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China
82Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
83Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China
84Department of Oncology, The Third People’s Hospital of Zhengzhou, Zhengzhou 450000, China
85Department of Biotherapy, State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
86Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha 410013, China
87Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
88Department of Cell Biology, College of Medicine, Jiaxing University, Jiaxing 314001, China
89Department of Medical, Shanghai OrigiMed Co, Ltd, Shanghai 201114, China
90Department of Medical, Menarini Silicon Biosystems SpA, Shanghai 200333, China
91Department of Medical, Geneplus-Beijing, Beijing 102200, China
92Department of Oncology, Baotou Cancer Hospital, Baotou 014000, China
93Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing 314000, China
94Department of Oncology, Lishui Municipal Central Hospital, Lishui 323000, China
95Department of Interventional Pulmonary Diseases, Anhui Chest Hospital, Hefei 230011, China
96Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
97Department of Medical Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200070, China
98Department of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250031, China
99Department of The Comprehensive Cancer Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
100Department of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032, China
101Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
102Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510060, China
103Department of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou 313000, China
104Department of Medical Oncology, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, China
105Department of Radiation Oncology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
106Department of Medical Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China
107Senior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing 100071, China
108Department of Pathology, Anhui Provincial Children’s Hospital, Hefei 230051, China
109Department of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
110Department of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210002, China
111Department of Clinical Oncology, The 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei 230031, China
112Department of Thoracic Surgery, Chuxiong Yi Autonomous Prefecture People’s Hospital, Chuxiong 675000, China
113Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
114Department of Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
115Department of Oncology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, China
116International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou 510632, China
117National Health Commission (NHC) Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
118Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing 210000, China
119Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China
120Department of Bone and Soft-tissue Surgery, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou 310022, China
121Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China
122Department of Oncology, The Cancer Hospital of Qinghai Province, Xining 810001, China
123Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
124Department of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
125Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
126Department of Thoracic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
127Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center, Westlake University School of Medicine, Hangzhou 310006, China
128Department of Breast Cancer and Urological Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
129Department of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
130Senior Department of Pathology, the 7th Medical Center of PLA General Hospital, Beijing 100700, China
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