Cancer Biology & Medicine

Cancer Biology & Medicine ›› 2025, Vol. 22 ›› Issue (3) : 266 - 283. DOI: 10.20892/j.issn.2095-3941.2024.0540

Orginal Article

MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer

Ningxin Ren ¹ ,
Hongxia Chen ¹ ,
Ying Huang ¹^,² ,
Jing Jin ³^,⁴ ,
Shaosen Zhang ¹ ,
Ruoqing Yan ¹ ,
Mengjie Li ¹ ,
Linlin Zheng ¹ ,
Shuangmei Zou ⁵ ,
Yexiong Li ³ ,
Wen Tan ¹ ,
Dongxin Lin ¹^,⁶

Author information +

¹State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

²Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China

³Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

⁴Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518100, China

⁵Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

⁶Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China

Correspondence to: Wen Tan and Dongxin Lin, E-mail: tanwen@cicams.ac.cn and lindx@cicams.ac.cn

收起

Received	Accepted	Published
2024-11-29	2025-01-21
Issue Date
2026-11-06

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