Cancer Biology & Medicine

Cancer Biology & Medicine ›› 2025, Vol. 22 ›› Issue (12) : 1558 - 1577. DOI: 10.20892/j.issn.2095-3941.2025.0058

ORIGINAL ARTICLE

CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway

Chao Xu ¹^,²^,^* ,
Zekun Li ¹^,^* ,
Yueying Shan ¹^,^* ,
Chunhua She ¹ ,
Yanfang Yang ¹ ,
Tianxing Zhou ¹ ,
Yongjie Xie ¹ ,
Bo Ni ¹ ,
Chenyang Meng ¹ ,
Guangcong Shen ¹ ,
Boyang Fu ¹ ,
Guannan Sheng ¹ ,
Liangliang Wu ¹ ,
Jinlong Pei ¹ ,
Tiansuo Zhao ¹ ,
Song Gao ¹ ,
Hongwei Wang ¹ ,
Chengqi Deng ³ ,
Kaiyuan Wang ³ ,
Antao Chang ¹ ,
Chongbiao Huang ¹ ,
Lei Shi ⁴ ,
Shengyu Yang ⁵ ,
Jun Yu ¹ ,
Jihui Hao ¹ ,
Xiuchao Wang ¹

Author information +

¹Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China

²National Clinical Research Center for Cancer, Tianjin Cancer Hospital Airport Hospital, Tianjin 300060, China

³Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China

⁴Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China

⁵Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA

haojihui@tjmuch.com

wangxiuchao2008@163.com

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Received	Accepted	Published
2025-02-10	2025-07-24
Issue Date
2026-04-03

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