The blockage of a fine ore bin is a common problem during the process of the beneficiation and smelting of non-ferrous metal mine due to its inherent structure, the properties of fine ore and environmental factors. The treatment methods such as air gun and manual knocking are inefficient and labor-intensive, which cannot meet the production requirements. It is a feasible way to dredge the blockage of the fine ore bin by controlled blasting. The key to handling the blockage by blasting is to determine the explosive charge amount under the condition of ensuring safety. According to the blockage position and degree, two kinds of charge calculation formulas were used by analyzing the reason for the fine ore bin blockage, the characteristics of the blockage body and the principle of blasting dredging. One method is refer to the empirical formula of condensate disassembly blasting. The charge amount for viscous plugging is designed and calculated according to the slagging thickness. The calculations indicate that the charge for the upper part with a larger diameter is 0.59 kg, while the charge for the lower conical feeding port with a smaller diameter is 0.07 kg. The other method is according to the calculation principle of volume charge and the characteristics of the clogging body of the fine ore bin. The calculations indicate that the charge for the upper part with a larger diameter is 0.49~0.98 kg, while the charge for the lower part with a smaller diameter is 0.15~0.30 kg. The safety charge amount is determined through calculating the safety pressure by the Faupel correction formula and shock wave calculation. As a result, the charge amount for the upper part and the lower part are determined as 0.6 kg and 0.15 kg, respectively. During the implementation process, 15 blocked fine ore bins were treated by charge amounts not exceeding 0.6 kg and 0.15 kg, all of which were safely dredged as expected. The practice shows that the calculated charge amount is reasonable, and the safety measures are effective.