The prominent problem existed in the production and sales for Kabuki Mine of Wuhai Mining Co. is high rate of fine ore of raw ore, while the sale price of fine ore in market is the lowest so that costs are difficult to be covered. Therefore, it is of great significances for reducing costs and increasing benefits in mines to improve on-site blasting technology so as to improve blasting quality. In order to find new method to improve the blasting effect, numerical simulation of blasting in the zone of total explosion is realized based on different blasting schemes so that the technical problem of past single-hole numerical simulation is solved as well as the effects under different blasting conditions are with comprehensive and deep analysis. Finally, the scientific and reasonable technical scheme is proposed by optimizing blasting schemes combining with such three aspects as design, analysis and numerical simulation so that blasting costs are saved. The experimental study on hole-by-hole blasting with uncoupled charge in radial direction is designed and proposed through studying the influencing factors of blasting process on generation of fine ore and combining with existing technical plan of blasting for the mine. The numerical simulation of blasting scheme in blast zone is carried out based on the GDEM blasting simulation software and particle size is analyzed for simulation effects. The study showed that the rates of fine ore and block were decreased by 9.45% and 3.07% respectively, qualified lumpiness was increased by 12.52 % and blasting effects were significantly improved with the optimization scheme.