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Multifunctional Coating Based on Hyaluronic Acid Loaded With a Traditional Chinese Medicine Ingredient, Ophiopogon Saponin D, for Potential Application of Cardiovascular Stents
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Jingan Li1, Kun Zhang2, Xiaojing Sun1, Zhongna Zhang1, Xiao Luo3, Shaokang Guan1
Biosurface and Biotribology | 2026, 12(1) : e70017
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Biosurface and Biotribology | 2026, 12(1): e70017
• ORIGINAL RESEARCH •
Multifunctional Coating Based on Hyaluronic Acid Loaded With a Traditional Chinese Medicine Ingredient, Ophiopogon Saponin D, for Potential Application of Cardiovascular Stents
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Jingan Li1, Kun Zhang2, Xiaojing Sun1, Zhongna Zhang1, Xiao Luo3, Shaokang Guan1
Affiliations
  • 1School of Material Science and Engineering & Henan Province Key Laboratory of Advanced Light Alloys & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou, China
  • 2School of Life Science, Zhengzhou University, Zhengzhou, China
  • 3School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
About Author:

Jingan Li and Kun Zhang are co-first-authors.

doi: 10.1049/bsb2.70017
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Cardiovascular disease (CVD) is regarded as the leading cause of morbidity and mortality worldwide within recent decades. Stent intervention is one of the main methods for treating CVD due to its advantages of minimal trauma, fast recovery and fewer complications. However, the main function of existing drug-eluting stents is anti-hyperplasia, and their re-endothelialisation function is still insufficient and needs to be strengthened. In this study, a novel coating containing traditional Chinese medicine ingredient, Ophiopogon Saponin D (OPH), is designed to enhance the re-endothelialisation function of stents: firstly, the dopamine (DA) and hexanediamine (HD) were co-polymerised to the bare metal stent, endowing rich-amino surface (PDA/HD) for conjugating functional molecules by chemical reaction; thereafter hyaluronic acid (HA) containing OPH were conjugated to the PDA/HD. Our data suggested that the OPH coating promoted surface re-endothelialisation not only by directly enhancing proliferation/migration and inhibiting apoptosis of endothelial cells, but also by regulating macrophages to M2 phenotype and smooth muscle cells to contractile phenotype. Our study may provide inspiration for designing more novel biomaterial coatings using traditional Chinese medicine ingredient.

biocompatibility  /  biointerface  /  biomaterials  /  cardiovascular device  /  coatings
Jingan Li, Kun Zhang, Xiaojing Sun, Zhongna Zhang, Xiao Luo, Shaokang Guan. Multifunctional Coating Based on Hyaluronic Acid Loaded With a Traditional Chinese Medicine Ingredient, Ophiopogon Saponin D, for Potential Application of Cardiovascular Stents[J]. Biosurface and Biotribology, 2026 , 12 (1) : e70017 - . DOI: 10.1049/bsb2.70017
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Funding
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  • National Natural Science Foundation of China(U2004164)
  • Zhengzhou University Major Project Cultivation Special Project(125-32214076)
Appendix
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Year 2026 volume 12 Issue 1
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61
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Article Info
doi: 10.1049/bsb2.70017
  • Receive Date：2025-11-18
  • Online Date：2026-08-27
Article Data
Affiliations
History
  • Received：2025-11-18
  • Revised：2026-01-25
  • Accepted：2026-02-08
Funding
National Natural Science Foundation of China(U2004164)
Zhengzhou University Major Project Cultivation Special Project(125-32214076)
Affiliations
    1School of Material Science and Engineering & Henan Province Key Laboratory of Advanced Light Alloys & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou, China
    2School of Life Science, Zhengzhou University, Zhengzhou, China
    3School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

Corresponding:

Jingan Li ()
Xiao Luo ()
Shaokang Guan ()
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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