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One-Step Co-Deposition of Phase-Transited Protein and Zwitterionic Polymers for Robust Antifouling and Lubricious Coatings
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Zaiyan Zhang1, Yuhang Liu1, Pengfei Li1, Yuhao Zhang2, Jiawen Zhang2, Ziqian Zhao3, Li Xiang1
Biosurface and Biotribology | 2026, 12(1) : e70029
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Biosurface and Biotribology | 2026, 12(1): e70029
• ORIGINAL RESEARCH •
One-Step Co-Deposition of Phase-Transited Protein and Zwitterionic Polymers for Robust Antifouling and Lubricious Coatings
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Zaiyan Zhang1, Yuhang Liu1, Pengfei Li1, Yuhao Zhang2, Jiawen Zhang2, Ziqian Zhao3, Li Xiang1
Affiliations
  • 1School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, China
  • 2School of Materials Science and Engineering, State Key Laboratory of Engineering Materials for Major Infrastructure, Southeast University, Nanjing, China
  • 3School of Materials Science and Engineering, Central South University, Changsha, China
doi: 10.1049/bsb2.70029
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Developing protective coatings with desirable antifouling and lubricating capabilities is crucial for the long-term performance of implantable and interventional medical devices. However, stably immobilising functional materials onto diverse substrates without complex pretreatment remains a major challenge. Herein, we report a 'one-step co-deposition' strategy to prepare multifunctional coatings by synergising the amyloid-like phase transition of bovine serum albumin (BSA) with zwitterionic polymers. Phase-transited BSA (PTB), generated via rapid amyloid-like aggregation induced by the reduction of intramolecular disulfide bonds using tris(2-carboxyethyl)phosphine (TCEP), acts as a robust interfacial anchor. This anchor embeds zwitterionic polymers—including poly(sulfobetaine methacrylate) (PSBMA), poly(carboxybetaine methacrylate) (PCBMA) and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)—into a dense protein network, realising the rapid functionalisation of various material surfaces (e.g., metals, inorganic ceramics and hydrophobic polymers), forming ultrathin and superhydrophilic coatings. The resulting coatings exhibit outstanding resistance to nonspecific biofouling, inhibiting the adsorption from complex biological fluids, proteins and lipids by over 90%. Also, the strongly hydrated zwitterionic polymers enable an efficient lubrication ability, reducing the friction coefficient to an ultralow range of 0.005-0.015 under physiological conditions. This work presents a facile strategy that simultaneously integrates exceptional antifouling and ultra-lubricating properties, offering great potential for tailoring multifunctional surfaces on biomedical devices for bioengineering applications.

biomaterials  /  coatings  /  lubrication  /  surface modification
Zaiyan Zhang, Yuhang Liu, Pengfei Li, Yuhao Zhang, Jiawen Zhang, Ziqian Zhao, Li Xiang. One-Step Co-Deposition of Phase-Transited Protein and Zwitterionic Polymers for Robust Antifouling and Lubricious Coatings[J]. Biosurface and Biotribology, 2026 , 12 (1) : e70029 - . DOI: 10.1049/bsb2.70029
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Funding
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  • National Natural Science Foundation of China(52575203; 52305185; 52379119)
Appendix
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Year 2026 volume 12 Issue 1
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36
7
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Article Info
doi: 10.1049/bsb2.70029
  • Receive Date：2026-03-09
  • Online Date：2026-08-27
Article Data
Affiliations
History
  • Received：2026-03-09
  • Revised：2026-06-11
  • Accepted：2026-07-01
Funding
National Natural Science Foundation of China(52575203; 52305185; 52379119)
Affiliations
    1School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, China
    2School of Materials Science and Engineering, State Key Laboratory of Engineering Materials for Major Infrastructure, Southeast University, Nanjing, China
    3School of Materials Science and Engineering, Central South University, Changsha, China

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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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