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Investigation of the Long-Term Degradation Behaviour of Binary Mesoporous Bioactive Glass Nanoparticles
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Jing Tian1, Meng Luo2, Mi Chen3, Yanzi Zhao1, Bo Lei1
Biosurface and Biotribology | 2026, 12(1) : e70025
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Biosurface and Biotribology | 2026, 12(1): e70025
• ORIGINAL RESEARCH •
Investigation of the Long-Term Degradation Behaviour of Binary Mesoporous Bioactive Glass Nanoparticles
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Jing Tian1, Meng Luo2, Mi Chen3, Yanzi Zhao1, Bo Lei1
Affiliations
  • 1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China
  • 2School of Life Science and Technology, Xidian University, Xi'an, China
  • 3Shaanxi Key Laboratory of Biomedical Metallic Materials, Northwest Institute for Non-Ferrous Metal Research, Xi'an, China
doi: 10.1049/bsb2.70025
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Bioactive glass nanoparticles (BGNs) have attracted widespread attention in regenerative medicine owing to their excellent biocompatibility and tissue repair capacity. However, the ion release behaviour associated with the long-term degradation of BGNs doped with different functional elements remains unclear. Herein, binary silicate BGNs (BGN-Ca, BGN-Mg, BGN-Zn, BGN-Cu and BGN-Mn) were prepared, and their degradation behaviour in normal saline was systematically evaluated over a period of up to 150 days. The evolution of particle morphology and size, ion release and pH changes in solution was characterised in detail. The results showed that the degradation behaviours of BGNs doped with different elements differed markedly. BGN-Ca and BGN-Mg exhibited the fastest degradation rates characterised by rapid degradation accompanied by higher Si release, whereas BGN-Zn and BGN-Mn showed comparable total Si release but displayed 'fast-then-slow' and 'slow-then-fast' release patterns, respectively. Overall, the reactivity of metal ions can provide a preliminary prediction of early ion-exchange trends, but the actual degradation behaviour is also co-regulated by multiple factors, including doping content, crystalline structure and solubility. This study elucidates the intrinsic relationship among doped elements, structural state and degradation behaviour and provides an experimental support for the precise design and stability regulation of multicomponent functionalised BGNs.

bioactive glass  /  ion degradation and release  /  metal ion doping  /  silicate network structure
Jing Tian, Meng Luo, Mi Chen, Yanzi Zhao, Bo Lei. Investigation of the Long-Term Degradation Behaviour of Binary Mesoporous Bioactive Glass Nanoparticles[J]. Biosurface and Biotribology, 2026 , 12 (1) : e70025 - . DOI: 10.1049/bsb2.70025
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Funding
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  • Natural Science Basic Research Program of Shaanxi of China(2025JC-YBQN-1078)
  • Postdoctoral Research Funding Project of Shaanxi of China(2024BSHSDZZ041)
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Year 2026 volume 12 Issue 1
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Article Info
doi: 10.1049/bsb2.70025
  • Receive Date：2025-12-30
  • Online Date：2026-08-27
Article Data
Affiliations
History
  • Received：2025-12-30
  • Revised：2026-05-03
  • Accepted：2026-05-09
Funding
Natural Science Basic Research Program of Shaanxi of China(2025JC-YBQN-1078)
Postdoctoral Research Funding Project of Shaanxi of China(2024BSHSDZZ041)
Affiliations
    1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China
    2School of Life Science and Technology, Xidian University, Xi'an, China
    3Shaanxi Key Laboratory of Biomedical Metallic Materials, Northwest Institute for Non-Ferrous Metal Research, Xi'an, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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