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Biomimetic Collagen Matrix With Aligned Architecture and Featured Stiffness Relative to Breast Cancer Cell Behaviour
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Weilong Lin1, Manman Sun1, Ke Huang1, Hong Li1, 2
Biosurface and Biotribology | 2026, 12(1) : e70023
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Biosurface and Biotribology | 2026, 12(1): e70023
• ORIGINAL RESEARCH •
Biomimetic Collagen Matrix With Aligned Architecture and Featured Stiffness Relative to Breast Cancer Cell Behaviour
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Weilong Lin1, Manman Sun1, Ke Huang1, Hong Li1, 2
Affiliations
  • 1Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou, China
  • 2Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou, China
About Author:

The authors Weilong Lin and Manman Sun have equally contributed to the work.

doi: 10.1049/bsb2.70023
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Cancer progression has been shown to be accompanied by alterations in physical features of its microenvironment. In the study, we fabricated an aligned collagen fibre matrix, whose architecture in both micro-level and nano-level was similar to that of the matrix found around the breast tumour tissue. The modulus of matrix exhibited a stiffness similarly to that found in metastatic breast tumour tissue. On the tough substrate, MDA-MB-231 cells presented an increased migration rate along the alignment of fibre. The biomechanical properties of tumour cells were explored in situ by AFM. The stiffness of a single MDA-MB-231 cell on the aligned matrix was reduced when compared with that on the nonaligned one. Wound healing assay showed that tumour cells with compliant modulus moved fast along the alignment of collagen fibre matrix. The in vitro model effectively mimicked the tumour cell behaviour, which would be helpful for new therapeutic strategies to detect cancer progress.

architecture  /  collagen  /  invasion  /  MDA-MB-231  /  stiffness
Weilong Lin, Manman Sun, Ke Huang, Hong Li. Biomimetic Collagen Matrix With Aligned Architecture and Featured Stiffness Relative to Breast Cancer Cell Behaviour[J]. Biosurface and Biotribology, 2026 , 12 (1) : e70023 - . DOI: 10.1049/bsb2.70023
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Funding
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  • National Natural Science Foundation of China(31971284)
  • Guangdong Basic and Applied Basic Research Foundation(2024A1515013268)
  • The Fundamental Research Funds for Central Universities, China(21624101)
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Year 2026 volume 12 Issue 1
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61
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Article Info
doi: 10.1049/bsb2.70023
  • Receive Date：2025-10-31
  • Online Date：2026-08-27
Article Data
Affiliations
History
  • Received：2025-10-31
  • Revised：2026-04-22
  • Accepted：2026-04-23
Funding
National Natural Science Foundation of China(31971284)
Guangdong Basic and Applied Basic Research Foundation(2024A1515013268)
The Fundamental Research Funds for Central Universities, China(21624101)
Affiliations
    1Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou, China
    2Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou, China

Corresponding:

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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