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Electrostatically Assembled HA-DN/AMSN-TCS Coatings for Antibacterial Urinary Catheters
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Jiafeng Hu1, 2, Xiaojun Chen1, 2, Yingwei Chen3, Lin Wu1, 2, Chengxiong Lin1, 2
Biosurface and Biotribology | 2026, 12(1) : e70022
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Biosurface and Biotribology | 2026, 12(1): e70022
• ORIGINAL RESEARCH •
Electrostatically Assembled HA-DN/AMSN-TCS Coatings for Antibacterial Urinary Catheters
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Jiafeng Hu1, 2, Xiaojun Chen1, 2, Yingwei Chen3, Lin Wu1, 2, Chengxiong Lin1, 2
Affiliations
  • 1Key Laboratory of Metallurgical Equipment and Control Technology, Ministry of Education, Wuhan University of Science and Technology, Wuhan, China
  • 2Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science and Technology, Wuhan, China
  • 3School of Mathematics and Computer Science, Wuhan Polytechnic University, Wuhan, China
doi: 10.1049/bsb2.70022
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Catheter-associated urinary tract infections (CAUTIs) are a significant complication of indwelling urinary catheters, primarily caused by bacterial adhesion, biofilm formation and catheter-induced mechanical irritation. To reduce the risk of infection and enhance catheter safety and performance, this study developed an antibacterial lubricating coating. The coating was fabricated on a polytetrafluoroethylene (PTFE) substrate via electrostatic self-assembly, combining dopamine-modified hyaluronic acid-dopamine (HA-DN) as a biomimetic adhesive with aminated mesoporous silica nanoparticles (AMSN) serving as a long-acting drug delivery carrier loaded with triclosan (TCS). The results demonstrated that the prepared AMSN exhibited a uniform particle size of approximately 80 nm, an ordered mesoporous structure and a high drug-loading capacity, enabling sustained in vitro release of TCS for up to 144 h. Additionally, the composite multilayer coating significantly improved surface hydrophilicity and lubricity, exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus and maintained good biocompatibility. These findings highlight its potential for preventing CAUTIs and enhancing the safety of indwelling urinary catheters.

adhesion and friction  /  antifungi  /  antimicrobial  /  biointerface  /  biological adhesion
Jiafeng Hu, Xiaojun Chen, Yingwei Chen, Lin Wu, Chengxiong Lin. Electrostatically Assembled HA-DN/AMSN-TCS Coatings for Antibacterial Urinary Catheters[J]. Biosurface and Biotribology, 2026 , 12 (1) : e70022 - . DOI: 10.1049/bsb2.70022
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Funding
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  • National Natural Science Foundation of China(52205186)
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Year 2026 volume 12 Issue 1
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Article Info
doi: 10.1049/bsb2.70022
  • Receive Date：2025-12-29
  • Online Date：2026-08-27
Article Data
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History
  • Received：2025-12-29
  • Revised：2026-04-14
  • Accepted：2026-04-21
Funding
National Natural Science Foundation of China(52205186)
Affiliations
    1Key Laboratory of Metallurgical Equipment and Control Technology, Ministry of Education, Wuhan University of Science and Technology, Wuhan, China
    2Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science and Technology, Wuhan, China
    3School of Mathematics and Computer Science, Wuhan Polytechnic University, Wuhan, China

Corresponding:

Lin Wu ()
Chengxiong Lin ()
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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