Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (5) : 2529 - 2544. DOI: 10.1016/j.apsb.2025.03.041

ORIGINAL ARTICLES

Targeting the JAK2–STAT3–UCHL3–ENO1 axis suppresses glycolysis and enhances the sensitivity to 5-FU chemotherapy in TP53-mutant colorectal cancer

Haisong Xin ^a^,^b^,^c ,
Zitong Zhao ^b ,
Shichao Guo ^b ,
Ruoxi Tian ^d ,
Liying Ma ^b ,
Yang Yang ^f ,
Lianmei Zhao ^g ,
Guanglin Wang ^e ,
Baokun Li ^e ,
Xuhua Hu ^e ,
Yongmei Song ^b^,^* ,
Guiying Wang ^a^,^c^,^e^,^*

Author information +

^aDepartment of General Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

^bState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

^cHebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

^dDepartment of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

^eThe Second Department of General Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

^fDepartment of General Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

^gResearch Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

^* Corresponding authors.

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Received	Accepted	Published
2024-06-19	2024-12-20
Issue Date
2026-09-17

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