Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (5) : 2511 - 2528. DOI: 10.1016/j.apsb.2025.02.008

ORIGINAL ARTICLES

A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes

Manyun Chen ^a^,^b^,^c^,^d ,
Yilei Peng ^a^,^b^,^c^,^d ,
Yuhui Hu ^a^,^b^,^c^,^d ,
Zhiqiang Kang ^e ,
Ting Chen ^f ,
Yulong Zhang ^a^,^b^,^c^,^d ,
Xiaoping Chen ^a^,^b^,^c^,^d ,
Qing Li ^a^,^b^,^c^,^d ,
Zuyi Yuan ^g ,
Yue Wu ^g ,
Heng Xu ^h ,
Gan Zhou ^a^,^b^,^c^,^d ,
Tao Liu ⁱ ,
Honghao Zhou ^a^,^b^,^c^,^d ,
Chunsu Yuan ^j ,
Weihua Huang ^a^,^b^,^c^,^d^,^* ,
Wei Zhang ^a^,^b^,^c^,^d^,^*

Author information +

^aDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China

^bEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China

^cHunan Key Laboratory of Pharmacomicrobiomics, Changsha 410078, China

^dNational Clinical Research Center for Geriatric Disorders, Changsha 410008, China

^eZhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450007, China

^fKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, China

^gDepartment of Cardiology, Cardiovascular Research Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

^hDepartment of Laboratory Medicine, National Key Laboratory of Biotherapy/ Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

ⁱShenzhen Center for Chronic Disease Control and Prevention, Shenzhen 518020, China

^jDepartment of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA

^* Corresponding authors.

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Received	Accepted	Published
2024-08-21	2024-12-30
Issue Date
2026-09-17

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