Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (5) : 2498 - 2510. DOI: 10.1016/j.apsb.2025.02.028

ORIGINAL ARTICLES

Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses

Tiefeng Xu ^a ,
Kun Li ^d ,
Siyao Huang ^a ,
Konstantin I. Ivanov ^b ,
Sidi Yang ^b ,
Yanxi Ji ^a ,
Hanwei Zhang ^a ,
Wenbin Wu ^a ,
Ye He ^h ,
Qiang Zeng ^a ,
Feng Cong ^e ,
Qifan Zhou ^f ,
Yingjun Li ^c^,^f ,
Jian Pan ^a ,
Jincun Zhao ^b^,^c ,
Chunmei Li ^a ,
Xumu Zhang ^f^,^g ,
Liu Cao ^a^,^* ,
Deyin Guo ^a^,^b^,^c^,^d^,^*

Author information +

^aCentre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Guangzhou 518107, China

^bGuangzhou Laboratory, Bio-island, Guangzhou 510320, China

^cState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China

^dInstitute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of the Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

^eGuangdong Province Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, China

^fShenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, Shenzhen Grubbs Institute and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen 518000, China

^gMedi-X Pingshan, Southern University of Science and Technology, Shenzhen 518118, China

^hGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

^* Corresponding authors.

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Received	Accepted	Published
2024-10-14	2025-01-14
Issue Date
2026-09-17

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