A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway
aState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
bSchool of Pharmaceutical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China
cFaculty of Biology, Medicine and Health, the University of Manchester, Manchester M13 9PT, UK
dDepartment of Crystallography & Structural Biology, Institute of Physical Chemistry Blas Cabrera, Spanish National Research Council (CSIC), Madrid 28006, Spain
eMoE Frontiers Science Center for Precision Oncology, University of Macau, Macao 999078, China
fGMU-GIBH Joint School of Life Sciences, the Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou 510005, China
* Corresponding author.
收起