Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (4) : 1922 - 1937. DOI: 10.1016/j.apsb.2025.02.034

ORIGINAL ARTICLE

Identification of a JAK–STAT–miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions

Songyang Li ^a ,
Yongjie Liu ^a ,
Xiaofeng Yin ^b ,
Yao Yang ^b^,^c ,
Xinjia Liu ^a^,^d ,
Jiaxing Qiu ^e ,
Qinglan Yang ^a ,
Yana Li ^a ,
Zhiguo Tan ^f ,
Hongyan Peng ^a ,
Peiwen Xiong ^a ,
Shuting Wu ^a ,
Lanlan Huang ^a^,^d ,
Xiangyu Wang ^a ,
Sulai Liu ^f ,
Yuxing Gong ^g ,
Yuan Gao ^g ,
Lingling Zhang ^h ,
Junping Wang ⁱ ,
Yafei Deng ^a^,^* ,
Zhaoyang Zhong ^j^,^* ,
Youcai Deng ^b^,ⁱ^,^*

Author information +

^aPediatrics Research Institute of Hunan Province, the Affiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha 410007, China

^bDepartment of Clinical Hematology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China

^cDepartment of Pharmacy, the General Hospital of Western Theater Command of PLA, Chengdu 610083, China

^dThe School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children’s Hospital), Changsha 410007, China

^eDepartment of Biological Sciences, Columbia University, NY 10027, USA

^fDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha 410005, China

^gTranslational Medicine Research Center, Shanxi Medical University, Taiyuan 030001, China

^hInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China

ⁱState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing 400038, China

^jThe Fifth People’s Hospital of Chongqing, Chongqing 400062, China

^* Corresponding authors.

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Received	Accepted	Published
2024-10-15	2025-02-18
Issue Date
2026-09-17

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