Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (1) : 392 - 408. DOI: 10.1016/j.apsb.2024.10.005

ORIGINAL ARTICLE

Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy

Jintong Yang ^a ,
Yiteng Lu ^b^,^c^,^d^,^e ,
Kexin Hu ^f ,
Xinchen Zhang ^a ,
Wei Wang ^a ,
Deyong Ye ^a ,
Mingguang Mo ^a ,
Xin Xiao ^a ,
Xichen Wan ^b^,^c^,^d^,^e ,
Yuqing Wu ^b^,^c^,^d^,^e ,
Shuxian Zhang ^g ,
He Huang ^g ,
Zhibei Qu ^a ,
Yimin Hu ^a ,
Yu Cao ^f^,^* ,
Jiaxu Hong ^b^,^c^,^d^,^e^,^* ,
Lu Zhou ^a^,^h^,^*

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Received	Accepted	Published
2024-06-12	2024-10-08
Issue Date
2026-09-17

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