Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (2) : 692 - 706. DOI: 10.1016/j.apsb.2024.07.006

ORIGINAL ARTICLE

Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance

Siqi Zhang ^a ,
Xiaohui Ma ^d ,
Jiang Wu ^e ,
Jieting Shen ^a ,
Yuntao Shi ^a ,
Xingkai Wang ^a ,
Lin Xie ^b ,
Xiaona Sun ^a ,
Yuxuan Wu ^a ,
Hao Tian ^a ,
Xin Gao ^a ,
Xueyao Chen ^a ,
Hongyi Huang ^a ,
Lu Chen ^a ,
Xuekai Song ^a ,
Qichen Hu ^a ,
Hailong Zhang ^f ,
Feng Wang ^e^,^* ,
Zhao-Hui Jin ^c^,^* ,
Ming-Rong Zhang ^b^,^* ,
Rui Wang ^a^,^f^,^* ,
Kuan Hu ^a^,^b^,^*

Author information +

^aState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

^bDepartment of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan

^cDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan

^dDepartment of Vascular and Endovascular Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

^eDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 211166, China

^fKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, Lanzhou University, Lanzhou 730000, China

^* Corresponding authors.

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Received	Accepted	Published
2024-03-04	2024-07-01
Issue Date
2026-09-17

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