Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (1) : 409 - 423. DOI: 10.1016/j.apsb.2024.10.001

ORIGINAL ARTICLE

Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification

Li Li ^a^,^b^,^c^,^* ,
Yuezhou Wang ^a^,^b^,^c ,
Yiqiu Wang ^d ,
Xiaoyang Li ^a^,^b ,
Qihong Deng ^a^,^b ,
Fei Gao ^a^,^b ,
Wenhua Lian ^a^,^b ,
Yunzhan Li ^a^,^b ,
Fu Gui ^a^,^b ,
Yanling Wei ^a^,^b ,
Su-Jie Zhu ^e ,
Cai-Hong Yun ^e ,
Lei Zhang ^a ,
Zhiyu Hu ^a^,^b ,
Qingyan Xu ^a^,^b ,
Xiaobing Wu ^a^,^b ,
Lanfen Chen ^a ,
Dawang Zhou ^a ,
Jianming Zhang ^f ,
Fei Xia ^d^,^* ,
Xianming Deng ^a^,^b^,^c^,^g^,^*

Author information +

^aState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China

^bState-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen 361102, China

^cCancer Research Center of Xiamen University, Xiamen 361102, China

^dSchool of Chemistry and Molecular Engineering, NYU-ECNU Center for Computational Chemistry at NYU Shanghai, East China Normal University, Shanghai 200062, China

^eDepartment of Biochemistry and Biophysics, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

^fInstitute of Translational Medicine & Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China

^gDepartment of Hematology, the First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China

^* Corresponding authors.

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Received	Accepted	Published
2024-06-12	2024-08-28
Issue Date
2026-09-17

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