Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (2) : 1039 - 1055. DOI: 10.1016/j.apsb.2024.12.012

ORIGINAL ARTICLE

Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages

Xin Liu ^a^,^b^,^c ,
Yi Fang ^c ,
Mincong Huang ^d ,
Shiliang Tu ^b ,
Boan Zheng ^b ,
Hang Yuan ^b ,
Peng Yu ^b ,
Mengyao Lan ^d ,
Wu Luo ^c ,
Yongqiang Zhou ^e ,
Guorong Chen ^f ,
Zhe Shen ^g ,
Yi Wang ^c ,
Guang Liang ^a^,^c^,^d^,^*

Author information +

^aDepartment of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310014, China

^bDepartment of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310014, China

^cChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

^dZhejiang TCM Key Laboratory of Pharmacology and Translational Research of Natural Products, School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou 311399, China

^eDepartment of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China

^fDepartment of Pathology, the Affiliated Quzhou Hospital of Wenzhou Medical University, Quzhou 32400, China

^gThe Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

^* Corresponding author.

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Received	Accepted	Published
2024-06-01	2024-10-22
Issue Date
2026-09-17

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The hierarchy quorum sensing network in Pseudomonas aeruginosa

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