Synthesis, preclinical evaluation and pilot clinical study of a P2Y12 receptor targeting radiotracer [18F]QTFT for imaging brain disorders by visualizing anti-inflammatory microglia
aSchool of Pharmacy, MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Zhongshan Hospital, Fudan University, Shanghai 201203, China
bPET Center, Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
cDepartment of Neurosurgery, Minhang Hospital, Fudan University, Shanghai 201199, China
dDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China
eDepartment of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai 201203, China
fShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
gThe Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, State Key Laboratory of Biomedical Imaging Science and System, Shenzhen 518055, China
* Corresponding authors.
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